Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYSLTR1 | Q9Y271 | 10/20 | 0.55 |
| ▸ | CYSLTR2 | Q9NS75 | 9/20 | 0.55 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.45 |
| ▸ | PPARG | P37231 | 3/20 | 0.45 |
| ▸ | PLA2G4A | P47712 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | PTGES | O14684 | 1/20 | 0.39 |
| ▸ | XPO1 | O14980 | 1/20 | 0.39 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.39 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.39 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.39 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.39 |
| ▸ | EGFR | P00533 | 1/20 | 0.39 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.39 |
| ▸ | PGR | P06401 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.39 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | RARB | P10826 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8998161 | 0.90 | CYSLTR1 (0.44) | CYSLTR1CYSLTR2EPHX2PPARGMAPT | |
| SCHEMBL8998257 | 0.88 | CYSLTR1 (0.47) | CYSLTR1CYSLTR2EPHX2PPARGPLA2G4A | |
| SCHEMBL6357802 | 0.86 | CYSLTR1 (0.73) | CYSLTR1CYSLTR2EPHX2PPARGPLA2G4A | |
| SCHEMBL8951514 | 0.86 | CYSLTR1 (0.72) | CYSLTR1CYSLTR2EPHX2PPARGPLA2G4A | |
| SCHEMBL4294287 | 0.85 | CYSLTR2 (0.53) | CYSLTR1CYSLTR2EPHX2PPARGPLA2G4A | |
| SCHEMBL3683219 | 0.83 | CYSLTR1 (0.51) | CYSLTR1CYSLTR2EPHX2PPARGPLA2G4A | |
| SCHEMBL6716972 | 0.82 | CYSLTR1 (0.50) | CYSLTR1CYSLTR2EPHX2PPARGPLA2G4A | |
| Toluene SCHEMBL9010944 | 0.82 | CYSLTR2 (0.59) | CYSLTR1CYSLTR2EPHX2PPARGPLA2G4A | |
| SCHEMBL10562495 | 0.81 | CYSLTR2 (0.44) | CYSLTR1CYSLTR2 | |
| SCHEMBL9586166 | 0.80 | CYSLTR2 (0.60) | CYSLTR1CYSLTR2EPHX2PPARGPLA2G4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0227241-B1 | Medicinal indole and indazole keto sulphone derivatives | ZENECA INC (US) | 1996-09-11 | — | — | EP | disclosed |
| US-4837235-A | ANTIALLERGENS, ANTIINFLAMMATORY AGENTS | ICI AMERICAS INC. (US) | 1989-06-06 | — | — | US | disclosed |
| EP-0227241-A2 | Medicinal indole and indazole keto sulphone derivatives | ZENECA INC. (US) | 1987-07-01 | — | — | EP | disclosed |