Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYSLTR1 | Q9Y271 | 9/20 | 0.44 |
| ▸ | CYSLTR2 | Q9NS75 | 2/20 | 0.44 |
| ▸ | EPHX2 | P34913 | 7/20 | 0.43 |
| ▸ | PPARG | P37231 | 7/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8998136 | 0.90 | CYSLTR1 (0.55) | CYSLTR1CYSLTR2EPHX2PPARGMAPT | |
| SCHEMBL8951512 | 0.85 | NPC1 (0.44) | CYSLTR1CYSLTR2EPHX2PPARGTP53 | |
| SCHEMBL8951557 | 0.83 | EPHX2 (0.52) | EPHX2TP53ALDH1A1EPHX1NPC1 | |
| SCHEMBL10562495 | 0.81 | CYSLTR2 (0.44) | CYSLTR1CYSLTR2LMNA | |
| SCHEMBL4466433 | 0.80 | CYSLTR1 (0.60) | CYSLTR1CYSLTR2EPHX2PPARGMAPT | |
| SCHEMBL8998257 | 0.78 | CYSLTR1 (0.47) | CYSLTR1CYSLTR2EPHX2PPARGMAPT | |
| SCHEMBL6357802 | 0.76 | CYSLTR1 (0.73) | CYSLTR1CYSLTR2EPHX2PPARGMAPT | |
| SCHEMBL8951514 | 0.76 | CYSLTR1 (0.72) | CYSLTR1CYSLTR2EPHX2PPARGMAPT | |
| SCHEMBL8998156 | 0.76 | CYSLTR1 (0.75) | CYSLTR1CYSLTR2EPHX2PPARG | |
| SCHEMBL4468804 | 0.75 | CYSLTR1 (0.59) | CYSLTR1CYSLTR2EPHX2PPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0227241-B1 | Medicinal indole and indazole keto sulphone derivatives | ZENECA INC (US) | 1996-09-11 | — | — | EP | disclosed |
| US-4837235-A | ANTIALLERGENS, ANTIINFLAMMATORY AGENTS | ICI AMERICAS INC. (US) | 1989-06-06 | — | — | US | disclosed |
| EP-0227241-A2 | Medicinal indole and indazole keto sulphone derivatives | ZENECA INC. (US) | 1987-07-01 | — | — | EP | disclosed |