SCHEMBL8998220

SCHEMBL8998220

CO[Si](OC)(c1ccccc1Br)C(C)(C)C

nearest known ligand 0.33

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 1/20 0.33
NQO2 P16083 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL445217 0.74 ALDH1A1 (0.39) ALDH1A1NQO2
SCHEMBL9634396 0.71 ALDH1A1 (0.36) ALDH1A1NQO2
SCHEMBL277279 0.70 MAPK1 (0.36) ALDH1A1
SCHEMBL432652 0.67 MAPK1 (0.33) ALDH1A1
SCHEMBL8422038 0.67 CYP2A6 (0.35) ALDH1A1
SCHEMBL707057 0.66 NR1H2 (0.30)
SCHEMBL31168893 0.66 ALDH1A1 (0.43) ALDH1A1NQO2
SCHEMBL3761218 0.66 ALDH1A1 (0.43) ALDH1A1NQO2
SCHEMBL5089853 0.64 NQO2 (0.37) ALDH1A1NQO2
Methoxymethane SCHEMBL28099062 0.64 ALDH1A1 (0.53) ALDH1A1NQO2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0728140-A1 NEW STEROIDS WITH RADICAL-ATTRACTING AROMATIC SUBSTITUENTS, PROCESS FOR THE PRODUCTION THEREOF AND PHARMACEUTICAL COMPOUNDS CONTAINING THE SAID SUBSTANCES Jenapharm GmbH & Co. KG (DE) 1996-08-28 EP disclosed
WO-1995013287-A1 NEW STEROIDS WITH RADICAL-ATTRACTING AROMATIC SUBSTITUENTS, PROCESS FOR THE PRODUCTION THEREOF AND PHARMACEUTICAL COMPOUNDS CONTAINING THE SAID SUBSTANCES JENAPHARM GMBH (DE) 1995-05-18 WO disclosed