Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 1/20 | 0.56 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.56 |
| ▸ | CYSLTR2 | Q9NS75 | 8/20 | 0.55 |
| ▸ | CYSLTR1 | Q9Y271 | 8/20 | 0.55 |
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.52 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.52 |
| ▸ | NAMPT | P43490 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8998153 | 0.93 | EPHX2 (0.66) | EPHX2NR1H4CYSLTR2CYSLTR1 | |
| SCHEMBL10368754 | 0.92 | EPHX2 (0.65) | EPHX2NR1H4CYSLTR2CYSLTR1LMNA | |
| SCHEMBL8998132 | 0.88 | CYSLTR2 (0.52) | EPHX2NR1H4CYSLTR2CYSLTR1 | |
| SCHEMBL9479108 | 0.88 | EPHX2 (0.58) | EPHX2NR1H4CYSLTR2CYSLTR1LMNA | |
| SCHEMBL9478778 | 0.86 | CYSLTR2 (0.54) | EPHX2NR1H4CYSLTR2CYSLTR1LMNA | |
| SCHEMBL9479238 | 0.86 | AAK1 (0.47) | EPHX2NR1H4CYSLTR2CYSLTR1LMNA | |
| SCHEMBL9479292 | 0.86 | EPHX2 (0.56) | EPHX2NR1H4CYSLTR2CYSLTR1LMNA | |
| SCHEMBL9479001 | 0.85 | CYSLTR1 (0.60) | EPHX2NR1H4CYSLTR2CYSLTR1 | |
| SCHEMBL9479142 | 0.84 | CYSLTR2 (0.57) | CYSLTR2CYSLTR1LMNANAMPT | |
| SCHEMBL8951100 | 0.84 | CYSLTR2 (0.53) | CYSLTR2CYSLTR1LMNAKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0227241-B1 | Medicinal indole and indazole keto sulphone derivatives | ZENECA INC (US) | 1996-09-11 | — | — | EP | disclosed |
| US-5234942-A | Treating allergic pulmonary disorders, asthma | ICI AMERICAS INC. (US) | 1993-08-10 | — | — | US | disclosed |
| US-4997844-A | Compounds for the treatment of allergic or inflammatory diseases or shock conditions | ICI AMERICAS INC. (US) | 1991-03-05 | — | — | US | disclosed |
| EP-0179619-B1 | HETEROCYCLIC AMIDES | ICI AMERICAS INC. (US) | 1990-09-05 | — | — | EP | disclosed |
| US-4837235-A | ANTIALLERGENS, ANTIINFLAMMATORY AGENTS | ICI AMERICAS INC. (US) | 1989-06-06 | — | — | US | disclosed |
| EP-0227241-A2 | Medicinal indole and indazole keto sulphone derivatives | ZENECA INC. (US) | 1987-07-01 | — | — | EP | disclosed |
| EP-0179619-A1 | Heterocyclic amides | ICI AMERICAS INC. (US) | 1986-04-30 | — | — | EP | disclosed |