SCHEMBL8998580

SCHEMBL8998580

CC1OC(=O)C[C@@H]1c1ccccc1

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP2C19 P33261 2/20 0.56
CYP2C9 P11712 1/20 0.56
SMN1; SMN2 Q16637 1/20 0.41
MEN1 O00255 1/20 0.40
KMT2A Q03164 1/20 0.40
MAOB P27338 3/20 0.40
HSD17B2 P37059 2/20 0.40
KDM4E B2RXH2 1/20 0.40
ADORA3 P0DMS8 1/20 0.40
AR P10275 1/20 0.40
CYP19A1 P11511 1/20 0.40
HSD17B10 Q99714 1/20 0.40
CA2 P00918 1/20 0.39
ALDH1A1 P00352 1/20 0.39
SIGMAR1 Q99720 1/20 0.39
GAA P10253 2/20 0.38
MAPT P10636 1/20 0.38
MAOA P21397 2/20 0.38
KDM1A O60341 1/20 0.38
CYP2B6 P20813 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14619614 1.00 CYP2C19 (0.56) CYP2C19CYP2C9SMN1; SMN2MEN1KMT2A
SCHEMBL15482008 1.00 CYP2C19 (0.56) CYP2C19CYP2C9SMN1; SMN2MEN1KMT2A
SCHEMBL14619613 1.00 CYP2C19 (0.56) CYP2C19CYP2C9SMN1; SMN2MEN1KMT2A
SCHEMBL21553352 0.80 CYP2C19 (0.80) CYP2C19CYP2C9MEN1KMT2AMAOB
SCHEMBL6779019 0.74 CYP2C19 (0.53) CYP2C19CYP2C9SMN1; SMN2MEN1KMT2A
SCHEMBL11309348 0.74 CYP2C19 (0.53) CYP2C19CYP2C9SMN1; SMN2MEN1KMT2A
SCHEMBL28507784 0.74 CYP2C19 (0.45) CYP2C19CYP2C9SMN1; SMN2MAOBHSD17B2
SCHEMBL29018351 0.74 CYP2C19 (0.45) CYP2C19CYP2C9SMN1; SMN2MAOBHSD17B2
SCHEMBL10980071 0.74 CYP2C19 (0.45) CYP2C19CYP2C9SMN1; SMN2MAOBHSD17B2
SCHEMBL9655969 0.73 CYP2C19 (0.51) CYP2C19CYP2C9MAOBKDM4EADORA3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0258967-B2 Process for producing optically active alcohols TAKASAGO PERFUMERY CO LTD (JP) 1996-08-21 EP disclosed
US-4962242-A HYDROGENATING OLEFINIC ALCOHOL USING AS CATALYST A RUTHENIUM-OPTICALLY ACTIVE PHOSPHINE COMPLEX TAKASAGO PERFUMERY CO., LTD. (JP) 1990-10-09 US disclosed
EP-0258967-A2 Process for producing optically active alcohols Takasago Perfumery Co., Ltd. (JP) 1988-03-09 EP disclosed