SCHEMBL8998730

SCHEMBL8998730

CN1C(=S)C(CCCC(=O)O)c2ccccc21

nearest known ligand 0.84

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
EGFR P00533 5/20 0.84
SRC P12931 1/20 0.48
CDC25A P30304 1/20 0.44
MAPT P10636 1/20 0.41
DUSP3 P51452 1/20 0.41
MCL1 Q07820 1/20 0.41
CTDSP1 Q9GZU7 1/20 0.41
HDAC4 P56524 2/20 0.39
HDAC7 Q8WUI4 2/20 0.39
HDAC5 Q9UQL6 2/20 0.39
TOP1 P11387 1/20 0.39
APEX1 P27695 2/20 0.38
NPSR1 Q6W5P4 1/20 0.38
FABP4 P15090 2/20 0.37
FABP5 Q01469 2/20 0.37
KMT2A Q03164 2/20 0.36
MEN1 O00255 1/20 0.36
LMNA P02545 1/20 0.36
HDAC3 O15379 1/20 0.36
MAPK1 P28482 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1388695 0.92 EGFR (1.00) EGFRSRCCDC25AMAPTDUSP3
SCHEMBL1388508 0.85 EGFR (0.66) EGFRSRCCDC25AHDAC4HDAC7
SCHEMBL8998910 0.84 EGFR (0.60) EGFRCDC25AMAPTDUSP3MCL1
SCHEMBL1388665 0.84 EGFR (0.76) EGFRSRCCDC25AHDAC4HDAC7
SCHEMBL8999377 0.80 EGFR (0.73) EGFRSRCCDC25AHDAC4HDAC7
SCHEMBL8811499 0.79 EGFR (0.78) EGFRSRCCDC25AMAPTHDAC4
SCHEMBL1388657 0.77 EGFR (0.70) EGFRSRCCDC25ALMNASMN1; SMN2
SCHEMBL8998975 0.75 EGFR (0.72) EGFRSRCCDC25AMAPTHDAC4
SCHEMBL1388649 0.73 EGFR (0.60) EGFRSRCCDC25AHDAC4HDAC7
SCHEMBL8993220 0.72 EGFR (0.58) EGFRMAPTHDAC4HDAC7HDAC5

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5556874-A ENZYME INHIBITORS AS ANTICARCINOGENIC AGENTS WARNER LAMBERT COMPANY (US) 1996-09-17 US claimed
EP-0654024-A1 2-THIOINDOLES (SELENOINDOLES) AND RELATED DISULFIDES (SELENIDES) WHICH INHIBIT PROTEIN TYROSINE KINASES AND WHICH HAVE ANTITUMOR PROPERTIES WARNER-LAMBERT COMPANY (US) 1995-05-24 EP claimed
US-5556874-A ENZYME INHIBITORS AS ANTICARCINOGENIC AGENTS WARNER LAMBERT COMPANY (US) 1996-09-17 US disclosed
US-5464861-A Anticarcinogenic agents WARNER-LAMBERT (US) 1995-11-07 US disclosed
EP-0654024-A1 2-THIOINDOLES (SELENOINDOLES) AND RELATED DISULFIDES (SELENIDES) WHICH INHIBIT PROTEIN TYROSINE KINASES AND WHICH HAVE ANTITUMOR PROPERTIES WARNER-LAMBERT COMPANY (US) 1995-05-24 EP disclosed
WO-1994003427-A1 2-THIOINDOLES (SELENOINDOLES) AND RELATED DISULFIDES (SELENIDES) WHICH INHIBIT PROTEIN TYROSINE KINASES AND WHICH HAVE ANTITUMOR PROPERTIES WARNER-LAMBERT COMPANY (US) 1994-02-17 WO disclosed