SCHEMBL8998975

SCHEMBL8998975

CN1C(=O)C(CCC(=O)O)c2ccccc21

nearest known ligand 0.72

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
EGFR P00533 4/20 0.72
CDC25A P30304 1/20 0.47
NPSR1 Q6W5P4 2/20 0.45
ALDH1A1 P00352 3/20 0.44
KDM4E B2RXH2 2/20 0.44
HPGD P15428 1/20 0.44
MEN1 O00255 3/20 0.43
KMT2A Q03164 3/20 0.43
LMNA P02545 2/20 0.43
GAA P10253 1/20 0.43
SMN1; SMN2 Q16637 1/20 0.43
L3MBTL1 Q9Y468 1/20 0.43
MAPT P10636 1/20 0.42
HDAC4 P56524 1/20 0.42
HDAC7 Q8WUI4 1/20 0.42
HDAC5 Q9UQL6 1/20 0.42
SRC P12931 1/20 0.39
PSEN1 P49768 2/20 0.38
PSEN2 P49810 2/20 0.38
APH1B Q8WW43 2/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8998910 0.91 EGFR (0.60) EGFRCDC25ANPSR1ALDH1A1KDM4E
SCHEMBL8811499 0.89 EGFR (0.78) EGFRCDC25ANPSR1KDM4EMEN1
SCHEMBL8727194 0.84 CDC25A (0.63) EGFRCDC25ANPSR1ALDH1A1KDM4E
SCHEMBL8999120 0.84 EGFR (0.52) EGFRCDC25ANPSR1ALDH1A1KDM4E
SCHEMBL1388695 0.84 EGFR (1.00) EGFRCDC25ANPSR1KDM4EMEN1
SCHEMBL28870561 0.82 KDM4E (0.64) EGFRNPSR1ALDH1A1KDM4EHPGD
SCHEMBL30099701 0.82 KDM4E (0.64) EGFRNPSR1ALDH1A1KDM4EHPGD
SCHEMBL8488571 0.81 ALDH1A1 (0.53) EGFRCDC25ANPSR1ALDH1A1KDM4E
SCHEMBL16822181 0.80 ALDH1A1 (0.47) EGFRCDC25ANPSR1ALDH1A1KDM4E
SCHEMBL8999056 0.79 EGFR (0.47) EGFRCDC25ANPSR1ALDH1A1KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5556874-A ENZYME INHIBITORS AS ANTICARCINOGENIC AGENTS WARNER LAMBERT COMPANY (US) 1996-09-17 US disclosed
US-5464861-A Anticarcinogenic agents WARNER-LAMBERT (US) 1995-11-07 US disclosed
EP-0654024-A1 2-THIOINDOLES (SELENOINDOLES) AND RELATED DISULFIDES (SELENIDES) WHICH INHIBIT PROTEIN TYROSINE KINASES AND WHICH HAVE ANTITUMOR PROPERTIES WARNER-LAMBERT COMPANY (US) 1995-05-24 EP disclosed
WO-1994003427-A1 2-THIOINDOLES (SELENOINDOLES) AND RELATED DISULFIDES (SELENIDES) WHICH INHIBIT PROTEIN TYROSINE KINASES AND WHICH HAVE ANTITUMOR PROPERTIES WARNER-LAMBERT COMPANY (US) 1994-02-17 WO disclosed