Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 4/20 | 0.74 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.67 |
| ▸ | ITGB2 | P05107 | 5/20 | 0.66 |
| ▸ | ICAM1 | P05362 | 5/20 | 0.66 |
| ▸ | ITGAL | P20701 | 5/20 | 0.66 |
| ▸ | ECE1 | P42892 | 3/20 | 0.60 |
| ▸ | FPR2 | P25090 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11379169 | 1.00 | ACE (0.74) | ACEALOX15ITGB2ICAM1ITGAL | |
| SCHEMBL5189433 | 0.88 | ACE (0.82) | ACEALOX15ITGB2ICAM1ITGAL | |
| SCHEMBL8466953 | 0.88 | ACE (0.82) | ACEALOX15ITGB2ICAM1ITGAL | |
| SCHEMBL28621122 | 0.87 | KMT2A (0.66) | ACE | |
| SCHEMBL22216055 | 0.86 | ACE (0.80) | ACEALOX15ITGB2ICAM1ITGAL | |
| SCHEMBL8999413 | 0.86 | EGFR (0.64) | ACE | |
| SCHEMBL8999055 | 0.86 | EGFR (0.64) | ACE | |
| SCHEMBL3857226 | 0.85 | ALOX15 (0.74) | ACEALOX15ITGB2ICAM1ITGAL | |
| SCHEMBL3857229 | 0.85 | ALOX15 (0.74) | ACEALOX15ITGB2ICAM1ITGAL | |
| SCHEMBL31606494 | 0.85 | ACE (0.79) | ACEALOX15ITGB2ICAM1ITGAL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4283337-A | Process for the purification of tryptophane and derivatives of tryptophane | DEUTSCHE GOLD UND- SILBER-SCHEIDEANSTALT VORMALS ROESSLER (DE) | 1981-08-11 | — | — | US | claimed |
| US-5556874-A | ENZYME INHIBITORS AS ANTICARCINOGENIC AGENTS | WARNER LAMBERT COMPANY (US) | 1996-09-17 | — | — | US | disclosed |
| US-5464861-A | Anticarcinogenic agents | WARNER-LAMBERT (US) | 1995-11-07 | — | — | US | disclosed |
| EP-0654024-A1 | 2-THIOINDOLES (SELENOINDOLES) AND RELATED DISULFIDES (SELENIDES) WHICH INHIBIT PROTEIN TYROSINE KINASES AND WHICH HAVE ANTITUMOR PROPERTIES | WARNER-LAMBERT COMPANY (US) | 1995-05-24 | — | — | EP | disclosed |
| WO-1994003427-A1 | 2-THIOINDOLES (SELENOINDOLES) AND RELATED DISULFIDES (SELENIDES) WHICH INHIBIT PROTEIN TYROSINE KINASES AND WHICH HAVE ANTITUMOR PROPERTIES | WARNER-LAMBERT COMPANY (US) | 1994-02-17 | — | — | WO | disclosed |
| US-4283337-A | Process for the purification of tryptophane and derivatives of tryptophane | DEUTSCHE GOLD UND- SILBER-SCHEIDEANSTALT VORMALS ROESSLER (DE) | 1981-08-11 | — | — | US | disclosed |