Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE2A | O00408 | 4/20 | 0.40 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.39 |
| ▸ | GSK3B | P49841 | 2/20 | 0.38 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.38 |
| ▸ | EPHX1 | P07099 | 2/20 | 0.36 |
| ▸ | KDM1A | O60341 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | PLA2G7 | Q13093 | 1/20 | 0.34 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.34 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.34 |
| ▸ | SOAT1 | P35610 | 4/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9000745 | 0.94 | EPHX1 (0.41) | ABCB1MAPK14EPHX1KDM1ASOAT1 | |
| SCHEMBL9000677 | 0.92 | EPHX1 (0.42) | PDE2AEPHX1SOAT1MAPT | |
| SCHEMBL9000497 | 0.89 | EPHX1 (0.38) | ABCB1MAPK14EPHX1SOAT1MAPT | |
| SCHEMBL9000445 | 0.89 | POLB (0.43) | ABCB1GSK3BMAPK14EPHX1SOAT1 | |
| SCHEMBL9000888 | 0.88 | EPHX1 (0.44) | EPHX1SOAT1 | |
| SCHEMBL9000458 | 0.88 | EPHX1 (0.41) | ABCB1GSK3BMAPK14EPHX1CYP3A4 | |
| SCHEMBL9000713 | 0.88 | EPHX1 (0.43) | GSK3BMAPK14EPHX1SOAT1MAPT | |
| SCHEMBL9000878 | 0.88 | EPHX1 (0.41) | ABCB1GSK3BMAPK14EPHX1CYP3A4 | |
| SCHEMBL9000744 | 0.86 | MAPT (0.38) | PDE2AGSK3BMAPK14NTRK1NTRK2 | |
| SCHEMBL9000671 | 0.86 | EPHX1 (0.34) | EPHX1SOAT1MAPTMEN1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5583147-A | INHIBITORS OF ACYL-COENZYME A: CHOLESTEROL O-TRANSFERASE; ANTIHYPERCHOLESTEROLEMIC AND/OR ANTIATHEROSCLEROTIC AGENTS | THE DUPONT MERCK PHARMACEUTICAL COMPANY (US) | 1996-12-10 | — | — | US | disclosed |