Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.38 |
| ▸ | LMNA | P02545 | 4/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | PDE2A | O00408 | 6/20 | 0.36 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.35 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.35 |
| ▸ | RECQL | P46063 | 1/20 | 0.35 |
| ▸ | GSK3B | P49841 | 2/20 | 0.34 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | SOAT1 | P35610 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9000902 | 0.93 | MAPT (0.42) | MAPTLMNAMEN1GAAKMT2A | |
| SCHEMBL9000802 | 0.90 | MAPT (0.39) | MAPTLMNAMEN1KMT2APDE2A | |
| SCHEMBL9000887 | 0.89 | LMNA (0.39) | MAPTLMNAMEN1GAAKMT2A | |
| SCHEMBL9000950 | 0.89 | MAPT (0.46) | MAPTLMNAMEN1GAAKMT2A | |
| SCHEMBL9000883 | 0.87 | MAPT (0.41) | MAPTLMNAMEN1GAAKMT2A | |
| SCHEMBL9000530 | 0.87 | MAPT (0.41) | MAPTLMNAMEN1GAAKMT2A | |
| SCHEMBL9000733 | 0.86 | PDE2A (0.40) | MAPTLMNAMEN1GAAKMT2A | |
| SCHEMBL9000592 | 0.82 | MAPT (0.44) | MAPTLMNAMEN1GAAKMT2A | |
| SCHEMBL9000815 | 0.81 | MAPT (0.50) | MAPTLMNAMEN1GAAKMT2A | |
| SCHEMBL9000677 | 0.80 | EPHX1 (0.42) | MAPTPDE2ANPSR1RECQLSOAT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5583147-A | INHIBITORS OF ACYL-COENZYME A: CHOLESTEROL O-TRANSFERASE; ANTIHYPERCHOLESTEROLEMIC AND/OR ANTIATHEROSCLEROTIC AGENTS | THE DUPONT MERCK PHARMACEUTICAL COMPANY (US) | 1996-12-10 | — | — | US | disclosed |