Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SOAT1 | P35610 | 7/20 | 0.41 |
| ▸ | SOAT2 | O75908 | 1/20 | 0.41 |
| ▸ | ACAT1 | P24752 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.31 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.31 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.31 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.31 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.31 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | PTGES | O14684 | 1/20 | 0.30 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9000769 | 0.91 | SOAT1 (0.44) | SOAT1SOAT2ACAT1GPR84POLB | |
| SCHEMBL9000680 | 0.90 | SOAT1 (0.45) | SOAT1SOAT2ACAT1GPR84HPGD | |
| SCHEMBL9000790 | 0.87 | SOAT1 (0.44) | SOAT1SOAT2ACAT1 | |
| SCHEMBL9000516 | 0.87 | SOAT1 (0.55) | SOAT1SOAT2ACAT1CYP3A4 | |
| SCHEMBL9000915 | 0.86 | SOAT1 (0.44) | SOAT1SOAT2ACAT1 | |
| SCHEMBL9000747 | 0.86 | SOAT1 (0.40) | SOAT1SOAT2ACAT1 | |
| SCHEMBL9000779 | 0.86 | SOAT1 (0.43) | SOAT1SOAT2ACAT1GPR84 | |
| SCHEMBL9000916 | 0.86 | SOAT1 (0.49) | SOAT1SOAT2ACAT1 | |
| SCHEMBL9000890 | 0.86 | SOAT1 (0.43) | SOAT1SOAT2ACAT1POLB | |
| SCHEMBL9000962 | 0.86 | SOAT1 (0.43) | SOAT1SOAT2ACAT1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5583147-A | INHIBITORS OF ACYL-COENZYME A: CHOLESTEROL O-TRANSFERASE; ANTIHYPERCHOLESTEROLEMIC AND/OR ANTIATHEROSCLEROTIC AGENTS | THE DUPONT MERCK PHARMACEUTICAL COMPANY (US) | 1996-12-10 | — | — | US | disclosed |