SCHEMBL900124

SCHEMBL900124

CCOC(=O)C1CCN(C(=O)O)CC1

nearest known ligand 0.70

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
MAPT P10636 2/20 0.70
ALDH1A1 P00352 6/20 0.66
CYP3A4 P08684 1/20 0.59
CYP2D6 P10635 1/20 0.59
CYP2C9 P11712 1/20 0.59
CYP2C19 P33261 1/20 0.59
KDM4E B2RXH2 3/20 0.57
GAA P10253 2/20 0.57
POLB P06746 1/20 0.56
SMN1; SMN2 Q16637 2/20 0.56
HSD17B10 Q99714 1/20 0.56
NPC1 O15118 1/20 0.56
RAB9A P51151 1/20 0.56
MEN1 O00255 1/20 0.55
KMT2A Q03164 1/20 0.55

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14810278 0.91 CHRM1 (0.61) MAPTALDH1A1CYP3A4CYP2D6CYP2C9
SCHEMBL21411461 0.89 ALDH1A1 (0.62) MAPTALDH1A1CYP3A4CYP2D6CYP2C9
SCHEMBL7427079 0.89 ALDH1A1 (0.58) MAPTALDH1A1CYP3A4CYP2D6CYP2C9
SCHEMBL14127719 0.89 MAPT (0.56) MAPTALDH1A1CYP3A4CYP2D6CYP2C9
SCHEMBL1720494 0.87 MAPT (0.72) MAPTALDH1A1CYP3A4CYP2D6CYP2C9
SCHEMBL28037969 0.85 CHRM1 (0.56) MAPTALDH1A1CYP3A4CYP2D6CYP2C9
SCHEMBL5885563 0.85 MAPT (0.70) MAPTALDH1A1CYP3A4CYP2D6CYP2C9
SCHEMBL2794847 0.84 MAPT (0.51) MAPTALDH1A1CYP3A4CYP2D6CYP2C9
SCHEMBL13733825 0.84 MAPT (0.51) MAPTALDH1A1CYP3A4CYP2D6CYP2C9
SCHEMBL16809642 0.84 MAPT (0.68) MAPTALDH1A1CYP3A4CYP2D6CYP2C9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 54 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4017855-A1 PYRAZOLO[3,4-B]PYRAZINE SHP2 PHOSPHATASE INHIBITORS Otsuka Pharmaceutical Co., Ltd. (JP) 2022-06-29 EP disclosed
EP-3947367-A1 PROTEIN TYROSINE PHOSPHATASE INHIBITORS Array Biopharma, Inc. (US) 2022-02-09 EP disclosed
EP-3856744-A1 MANUFACTURE OF COMPOUNDS AND COMPOSITIONS FOR INHIBITING THE ACTIVITY OF SHP2 Novartis AG (CH) 2021-08-04 EP disclosed
WO-2021127337-A1 TRPML MODULATORS CASMA THERAPEUTICS, INC. (US) 2021-06-24 WO disclosed
EP-3806855-A1 GLP-1 RECEPTOR AGONISTS AND USES THEREOF Pfizer Inc. (US) 2021-04-21 EP disclosed
US-10961225-B2 Bicyclic AZA compounds as muscarinic M1 receptor and/or M4 receptor HEPTARES THERAPEUTICS LIMITED (GB) 2021-03-30 US disclosed
WO-2021033153-A1 PYRAZOLO[3,4-B]PYRAZINE SHP2 PHOSPHATASE INHIBITORS OTSUKA PHARMACEUTICAL CO., LTD. (JP) 2021-02-25 WO disclosed
EP-3774805-A1 HETEROBICYCLIC INHIBITORS OF MAT2A AND METHODS OF USE FOR TREATING CANCER Agios Pharmaceuticals, Inc. (US) 2021-02-17 EP disclosed
US-20200325118-A1 BICYCLIC AZA COMPOUNDS AS MUSCARINIC M1 RECEPTOR AND/OR M4 RECEPTOR NXERA PHARMA UK LIMITED (GB) 2020-10-15 US disclosed
WO-2020201991-A1 PROTEIN TYROSINE PHOSPHATASE INHIBITORS ARRAY BIOPHARMA INC. (US) 2020-10-08 WO disclosed
EP-2280008-B1 HETEROCYCLIC-SUBSTITUTED PIPERIDINES AS ORL-1 LIGANDS PURDUE PHARMA LP (US) 2013-05-29 EP disclosed
WO-2012041872-A1 N-HETEROARYL COMPOUNDS WITH CYCLIC BRIDGING UNIT FOR THE TREATMENT OF PARASITIC DISEASES INTERVET INTERNATIONAL B.V. (NL) 2012-04-05 WO disclosed
EP-2397477-A1 Heterocyclic-substituted piperidine compounds and the uses thereof Purdue Pharma LP (US) 2011-12-21 EP disclosed
EP-2280008-A2 Heterocyclic-substituted piperidines as ORL-1 ligands Purdue Pharma L.P. (US) 2011-02-02 EP disclosed
EP-1789404-B1 SUBSTITUTED N-ARYLSULFONYLHETEROCYCLIC AMINES AS GAMMA-SECRETASE INHIBITORS SCHERING CORP (US) 2010-03-24 EP disclosed
WO-2010028254-A2 SUBSTITUTED QUINAZOLINE INHIBITORS OF GROWTH FACTOR RECEPTOR TYROSINE KINASES AUSPEK PHARMACEUTICALS, INC. (US) 2010-03-11 WO disclosed
EP-2049124-A2 PHOSPHORUS DERIVATIVES AS HISTONE DEACETYLASE INHIBITORS Merck & Co., Inc. (US) 2009-04-22 EP disclosed
WO-2008010985-A2 PHOSPHORUS DERIVATIVES AS HISTONE DEACETYLASE INHIBITORS MERCK & CO., INC. (US) 2008-01-24 WO disclosed
EP-1735313-A1 SUBSTITUTED DIAZA-SPIRO-[4.5|-DECANE DERIVATIVES AND THEIR USE AS NEUROKININ ANTAGONISTS JANSSEN PHARMACEUTICA N.V. (BE) 2006-12-27 EP disclosed
WO-2005097794-A1 SUBSTITUTED DIAZA-SPIRO-[4.5]-DECANE DERIVATIVES AND THEIR USE AS NEUROKININ ANTAGONISTS JANSSEN PHARMACEUTICA N.V. (BE) 2005-10-20 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20200325118-A1 BICYCLIC AZA COMPOUNDS AS MUSCARINIC M1 RECEPTOR AND/OR M4 RECEPTOR CHRM1, CHRM2, CHRM4 MAPT 3528/4885ALDH1A1 1306/4885CYP3A4 389/4885
US-10961225-B2 Bicyclic AZA compounds as muscarinic M1 receptor and/or M4 receptor CHRM1, CHRM2, CHRM4 MAPT 3528/4885ALDH1A1 1306/4885CYP3A4 389/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.