Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP17A1 | P05093 | 16/20 | 0.71 |
| ▸ | CYP1A2 | P05177 | 5/20 | 0.71 |
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.33 |
| ▸ | CNR1 | P21554 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL900497 | 0.83 | CYP17A1 (1.00) | CYP17A1CYP1A2 | |
| SCHEMBL903217 | 0.83 | CYP17A1 (1.00) | CYP17A1CYP1A2CNR1 | |
| SCHEMBL900105 | 0.81 | CYP17A1 (0.73) | CYP17A1CYP1A2 | |
| SCHEMBL28625938 | 0.80 | CYP17A1 (0.51) | CYP17A1CYP1A2NR1H4KDM4ELMNA | |
| SCHEMBL900391 | 0.79 | CYP17A1 (0.74) | CYP17A1CYP1A2NR1H4CNR1 | |
| SCHEMBL900217 | 0.76 | CYP17A1 (0.74) | CYP17A1CYP1A2NR1H4CNR1 | |
| SCHEMBL899348 | 0.76 | CYP17A1 (1.00) | CYP17A1CYP1A2KDM4E | |
| SCHEMBL903225 | 0.75 | CYP17A1 (0.70) | CYP17A1CYP1A2NR1H4CNR1 | |
| SCHEMBL900104 | 0.74 | CYP17A1 (1.00) | CYP17A1CYP1A2 | |
| SCHEMBL21555726 | 0.69 | CYP17A1 (0.54) | CYP17A1CYP1A2CNR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9133160-B2 | Substituted benzimidazole and imidazopyridine compounds useful as CYP17 modulators | BRISTOL-MEYERS SQUIBB COMPANY (US) | 2015-09-15 | — | — | US | claimed |
| EP-2621913-B1 | SUBSTITUTED BENZIMIDAZOLE AND IMIDAZOPYRIDINE COMPOUNDS USEFUL AS CYP17 MODULATORS | BRISTOL MYERS SQUIBB CO (US) | 2014-11-19 | — | — | EP | claimed |
| US-20130310393-A1 | SUBSTITUTED BENZIMIDAZOLE AND IMIDAZOPYRIDINE COMPOUNDS USEFUL AS CYP17 MODULATORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2013-11-21 | — | — | US | claimed |
| EP-2621913-A1 | SUBSTITUTED BENZIMIDAZOLE AND IMIDAZOPYRIDINE COMPOUNDS USEFUL AS CYP17 MODULATORS | Bristol-Myers Squibb Company (US) | 2013-08-07 | — | — | EP | claimed |
| WO-2012044537-A1 | SUBSTITUTED BENZIMIDAZOLE AND IMIDAZOPYRIDINE COMPOUNDS USEFUL AS CYP17 MODULATORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2012-04-05 | — | — | WO | claimed |
| US-9133160-B2 | Substituted benzimidazole and imidazopyridine compounds useful as CYP17 modulators | BRISTOL-MEYERS SQUIBB COMPANY (US) | 2015-09-15 | — | — | US | disclosed |
| US-9133160-B2 | Substituted benzimidazole and imidazopyridine compounds useful as CYP17 modulators | BRISTOL-MEYERS SQUIBB COMPANY (US) | 2015-09-15 | — | — | US | disclosed |
| US-9133160-B2 | Substituted benzimidazole and imidazopyridine compounds useful as CYP17 modulators | BRISTOL-MEYERS SQUIBB COMPANY (US) | 2015-09-15 | — | — | US | disclosed |
| EP-2621913-B1 | SUBSTITUTED BENZIMIDAZOLE AND IMIDAZOPYRIDINE COMPOUNDS USEFUL AS CYP17 MODULATORS | BRISTOL MYERS SQUIBB CO (US) | 2014-11-19 | — | — | EP | disclosed |
| EP-2621913-B1 | SUBSTITUTED BENZIMIDAZOLE AND IMIDAZOPYRIDINE COMPOUNDS USEFUL AS CYP17 MODULATORS | BRISTOL MYERS SQUIBB CO (US) | 2014-11-19 | — | — | EP | disclosed |
| US-20130310393-A1 | SUBSTITUTED BENZIMIDAZOLE AND IMIDAZOPYRIDINE COMPOUNDS USEFUL AS CYP17 MODULATORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2013-11-21 | — | — | US | disclosed |
| US-20130310393-A1 | SUBSTITUTED BENZIMIDAZOLE AND IMIDAZOPYRIDINE COMPOUNDS USEFUL AS CYP17 MODULATORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2013-11-21 | — | — | US | disclosed |
| WO-2012044537-A1 | SUBSTITUTED BENZIMIDAZOLE AND IMIDAZOPYRIDINE COMPOUNDS USEFUL AS CYP17 MODULATORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2012-04-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130310393-A1 | SUBSTITUTED BENZIMIDAZOLE AND IMIDAZOPYRIDINE COMPOUNDS USEFUL AS CYP17 MODULATORS | CYP3A43, CYP2C18, CYP3A7 | CYP17A1 40/4885CYP1A2 12/4885NR1H4 88/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.