SCHEMBL900290

SCHEMBL900290

Cc1cccc(OC(F)F)c1Cl

nearest known ligand 0.42

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 4/20 0.42
KMT2A Q03164 5/20 0.38
MEN1 O00255 4/20 0.38
MAPT P10636 4/20 0.38
P2RX7 Q99572 3/20 0.35
GAA P10253 1/20 0.35
SMN1; SMN2 Q16637 1/20 0.35
LRRK2 Q5S007 1/20 0.35
SLC6A4 P31645 1/20 0.35
DRD1 P21728 1/20 0.34
NR1I2 O75469 1/20 0.34
BACE1 P56817 1/20 0.34
HTT P42858 2/20 0.33
NPSR1 Q6W5P4 2/20 0.33
LMNA P02545 1/20 0.33
CYP11B1 P15538 1/20 0.33
POLB P06746 1/20 0.33
TDP1 Q9NUW8 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16961406 0.82 EZH2 (0.40) ALDH1A1KMT2AMEN1SLC6A4NPSR1
SCHEMBL16955002 0.79 MAPT (0.46) ALDH1A1KMT2AMEN1MAPTGAA
SCHEMBL1911968 0.79 TSHR (0.43) KMT2AMEN1SMN1; SMN2SLC6A4DRD1
SCHEMBL12474318 0.78 KMT2A (0.37) ALDH1A1KMT2AMEN1MAPTSMN1; SMN2
Ammonia Solution, Strong SCHEMBL28718346 0.77 TSHR (0.42) KMT2AMEN1SMN1; SMN2SLC6A4DRD1
SCHEMBL18257237 0.76 DRD1 (0.39) ALDH1A1KMT2AMEN1MAPTP2RX7
SCHEMBL25435045 0.76 ALDH1A1 (0.42) ALDH1A1KMT2AMEN1MAPTP2RX7
SCHEMBL8764050 0.76 CD44 (0.45) KMT2AMAPTSMN1; SMN2DRD1NR1I2
SCHEMBL900289 0.76 ALDH1A1 (0.42) ALDH1A1KMT2AMEN1MAPTP2RX7
SCHEMBL15233201 0.76 KMT2A (0.38) ALDH1A1KMT2AMEN1MAPTGAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2900645-A1 3-PHENYLISOXAZOLIN DERIVATIVES WITH HERBICIDAL ACTION Bayer CropScience AG (DE) 2015-08-05 EP disclosed
EP-2621922-A1 A PROCESS FOR THE SYNTHESIS OF THIO-TRIAZOLO-GROUP CONTAINING COMPOUNDS BASF SE (DE) 2013-08-07 EP disclosed
WO-2012041858-A1 A PROCESS FOR THE SYNTHESIS OF THIO-TRIAZOLO-GROUP CONTAINING COMPOUNDS BASF SE (DE) 2012-04-05 WO disclosed