SCHEMBL900416

SCHEMBL900416

[CH2]c1cccc(SC(F)(F)F)c1F

nearest known ligand 0.32

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 2/20 0.32
PKM P14618 1/20 0.32
HPGD P15428 1/20 0.32
HTT P42858 1/20 0.32
L3MBTL1 Q9Y468 1/20 0.32
PDE2A O00408 1/20 0.31
KDM4E B2RXH2 1/20 0.30
TDP1 Q9NUW8 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL476655 0.80 ALDH1A1 (0.38) ALDH1A1PKMHPGDHTTL3MBTL1
SCHEMBL2783365 0.77 ALDH1A1 (0.33) ALDH1A1PKMHPGDHTTL3MBTL1
SCHEMBL900417 0.75 SMN1; SMN2 (0.35) ALDH1A1PKMHPGDHTTL3MBTL1
SCHEMBL900552 0.75 ALOX5AP (0.32) ALDH1A1PKMHPGDHTTL3MBTL1
SCHEMBL10974613 0.75 CYP1A2 (0.32) ALDH1A1PKMHPGDHTTL3MBTL1
SCHEMBL900279 0.75 FFAR4 (0.36)
SCHEMBL16956373 0.74 MEN1 (0.33)
SCHEMBL2811681 0.71
SCHEMBL900168 0.71 KDM4E (0.30) ALDH1A1KDM4ETDP1
SCHEMBL900569 0.70 FFAR4 (0.36)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2621922-A1 A PROCESS FOR THE SYNTHESIS OF THIO-TRIAZOLO-GROUP CONTAINING COMPOUNDS BASF SE (DE) 2013-08-07 EP disclosed
WO-2012041858-A1 A PROCESS FOR THE SYNTHESIS OF THIO-TRIAZOLO-GROUP CONTAINING COMPOUNDS BASF SE (DE) 2012-04-05 WO disclosed