Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 12/20 | 0.44 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.36 |
| ▸ | DRD3 | P35462 | 4/20 | 0.35 |
| ▸ | DRD2 | P14416 | 3/20 | 0.35 |
| ▸ | DRD1 | P21728 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | HTR1A | P08908 | 1/20 | 0.35 |
| ▸ | DRD4 | P21917 | 1/20 | 0.35 |
| ▸ | HTR2A | P28223 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10082624 | 0.79 | PDE10A (0.66) | PDE10ANR1I2CYP3A4CYP2C9KCNH2 | |
| SCHEMBL899888 | 0.74 | PDE10A (0.67) | PDE10ANR1I2CYP3A4CYP2C9KCNH2 | |
| SCHEMBL19751912 | 0.68 | MAPT (0.39) | NPC1MAPTRAB9ALOXL2DRD3 | |
| SCHEMBL902411 | 0.65 | PDE10A (0.72) | PDE10ANR1I2CYP3A4CYP2C9KCNH2 | |
| SCHEMBL898782 | 0.65 | PDE10A (0.66) | PDE10ANR1I2CYP3A4CYP2C9KCNH2 | |
| SCHEMBL19751932 | 0.65 | PDE10A (0.66) | PDE10ANR1I2CYP3A4CYP2C9KCNH2 | |
| SCHEMBL2986628 | 0.65 | NPC1 (0.72) | PDE10ACYP3A4CYP2C9NPC1MAPT | |
| SCHEMBL19733058 | 0.65 | PDE10A (0.68) | PDE10ANR1I2CYP3A4CYP2C9KCNH2 | |
| SCHEMBL9642061 | 0.65 | MAPT (0.84) | CYP3A4CYP2C9NPC1MAPTRAB9A | |
| SCHEMBL11399187 | 0.65 | MAPT (0.84) | CYP3A4CYP2C9NPC1MAPTRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2621276-B1 | 2-ALKOXY PYRIMIDINE PDE10 INHIBITORS | MERCK SHARP & DOHME (US) | 2017-12-27 | — | — | EP | claimed |
| US-8785467-B2 | Alkoxy pyrimidine PDE10 inhibitors | MERCK SHARP & DOHME CORP. (US) | 2014-07-22 | — | — | US | claimed |
| EP-2621276-A2 | 2-ALKOXY PYRIMIDINE PDE10 INHIBITORS | Merck Sharp & Dohme Corp. (US) | 2013-08-07 | — | — | EP | claimed |
| US-20130158056-A1 | ALKOXY PYRIMIDINE PDE10 INHIBITORS | MERCK SHARP & DOHME LLC | 2013-06-20 | — | — | US | claimed |
| WO-2012044561-A2 | 2-ALKOXY PYRIMIDINE PDE10 INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2012-04-05 | — | — | WO | claimed |
| EP-2621276-B1 | 2-ALKOXY PYRIMIDINE PDE10 INHIBITORS | MERCK SHARP & DOHME (US) | 2017-12-27 | — | — | EP | disclosed |
| EP-2621276-B1 | 2-ALKOXY PYRIMIDINE PDE10 INHIBITORS | MERCK SHARP & DOHME (US) | 2017-12-27 | — | — | EP | disclosed |
| US-8785467-B2 | Alkoxy pyrimidine PDE10 inhibitors | MERCK SHARP & DOHME CORP. (US) | 2014-07-22 | — | — | US | disclosed |
| US-8785467-B2 | Alkoxy pyrimidine PDE10 inhibitors | MERCK SHARP & DOHME CORP. (US) | 2014-07-22 | — | — | US | disclosed |
| US-8785467-B2 | Alkoxy pyrimidine PDE10 inhibitors | MERCK SHARP & DOHME CORP. (US) | 2014-07-22 | — | — | US | disclosed |
| US-20130158056-A1 | ALKOXY PYRIMIDINE PDE10 INHIBITORS | MERCK SHARP & DOHME LLC | 2013-06-20 | — | — | US | disclosed |
| US-20130158056-A1 | ALKOXY PYRIMIDINE PDE10 INHIBITORS | MERCK SHARP & DOHME LLC | 2013-06-20 | — | — | US | disclosed |
| US-20130158056-A1 | ALKOXY PYRIMIDINE PDE10 INHIBITORS | MERCK SHARP & DOHME LLC | 2013-06-20 | — | — | US | disclosed |
| WO-2012044561-A2 | 2-ALKOXY PYRIMIDINE PDE10 INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2012-04-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130158056-A1 | ALKOXY PYRIMIDINE PDE10 INHIBITORS | PDE10A, PDE11A, PDE12 | PDE10A 1/4885NR1I2 4311/4885CYP3A4 3247/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.