Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 4/20 | 0.56 |
| ▸ | LMNA | P02545 | 3/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.56 |
| ▸ | USP2 | O75604 | 2/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.56 |
| ▸ | PKM | P14618 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 4/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.51 |
| ▸ | NCF1 | P14598 | 6/20 | 0.47 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.46 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | RECQL | P46063 | 1/20 | 0.44 |
| ▸ | GBA1 | P04062 | 1/20 | 0.41 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL900221 | 0.96 | HTT (0.60) | HTTLMNAMAPK1USP2HSD17B10 | |
| SCHEMBL900149 | 0.84 | HTT (0.77) | HTTLMNAMAPK1USP2HSD17B10 | |
| SCHEMBL899676 | 0.73 | KMT2A (0.52) | HTTLMNAMAPK1USP2HSD17B10 | |
| SCHEMBL900251 | 0.70 | HTT (0.62) | HTTLMNAMAPK1USP2HSD17B10 | |
| SCHEMBL900252 | 0.70 | HTT (0.62) | HTTLMNAMAPK1USP2HSD17B10 | |
| SCHEMBL8229816 | 0.70 | NCF1 (0.76) | HTTLMNAMAPK1USP2HSD17B10 | |
| SCHEMBL5065450 | 0.69 | NCF1 (0.88) | HTTLMNAMAPK1USP2HSD17B10 | |
| SCHEMBL31217463 | 0.68 | HTT (1.00) | HTTLMNAMAPK1USP2HSD17B10 | |
| SCHEMBL15286518 | 0.68 | SMO (0.52) | LMNAHSD17B10MEN1KMT2AMAPT | |
| SCHEMBL6125246 | 0.68 | NCF1 (0.75) | HTTLMNAMAPK1USP2HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2621923-A1 | N-HETEROARYL COMPOUNDS WITH CYCLIC BRIDGING UNIT FOR THE TREATMENT OF PARASITIC DISEASES | Intervet International B.V. (NL) | 2013-08-07 | — | — | EP | disclosed |
| WO-2012041872-A1 | N-HETEROARYL COMPOUNDS WITH CYCLIC BRIDGING UNIT FOR THE TREATMENT OF PARASITIC DISEASES | INTERVET INTERNATIONAL B.V. (NL) | 2012-04-05 | — | — | WO | disclosed |