Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 8/20 | 0.36 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.33 |
| ▸ | WNT3A | P56704 | 1/20 | 0.33 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8566959 | 0.89 | NOTUM (0.41) | CTNNB1WNT3ANOTUM | |
| SCHEMBL9486327 | 0.80 | KCNH2 (0.34) | KCNH2CTNNB1WNT3ANOTUM | |
| SCHEMBL22098111 | 0.77 | HTR2C (0.39) | KCNH2CTNNB1WNT3ANOTUM | |
| SCHEMBL9006824 | 0.75 | CTNNB1 (0.38) | KCNH2CTNNB1WNT3A | |
| SCHEMBL5440454 | 0.73 | KCNH2 (0.37) | KCNH2CTNNB1WNT3ANOTUM | |
| SCHEMBL6594574 | 0.72 | MAOB (0.39) | — | |
| SCHEMBL22681792 | 0.69 | HTR2C (0.39) | KCNH2CTNNB1WNT3A | |
| SCHEMBL8560705 | 0.68 | DYRK1A (0.41) | CTNNB1WNT3ANOTUM | |
| SCHEMBL436669 | 0.68 | KCNH2 (0.49) | KCNH2CTNNB1WNT3A | |
| SCHEMBL22681788 | 0.68 | HTR2C (0.43) | KCNH2CTNNB1WNT3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0571546-B1 | CHROMAN AND THIOCHROMANS WITH PHENYLETHYNYL SUBSTITUENTS AT THE 7-POSITION HAVING RETINOID-LIKE BIOLOGICAL ACTIVITY | ALLERGAN INC (US) | 1996-10-16 | — | — | EP | disclosed |
| US-5346915-A | Chromans and thiochromans with phenylethynyl substituents at the 7-position having retinold-like biological activity | ALLERGAN, INC. (US) | 1994-09-13 | — | — | US | disclosed |
| US-5346895-A | Treating dermatoses, immunological disorders, wound healing | ALLERGAN, INC. (US) | 1994-09-13 | — | — | US | disclosed |
| EP-0571546-A1 | CHROMAN AND THIOCHROMANS WITH PHENYLETHYNYL SUBSTITUENTS AT THE 7-POSITION HAVING RETINOID-LIKE BIOLOGICAL ACTIVITY. | ALLERGAN INC (US) | 1993-12-01 | — | — | EP | disclosed |
| WO-1992014725-A1 | CHROMAN AND THIOCHROMANS WITH PHENYLETHYNYL SUBSTITUENTS AT THE 7-POSITION HAVING RETINOID-LIKE BIOLOGICAL ACTIVITY | ALLERGAN, INC. (US) | 1992-09-03 | — | — | WO | disclosed |