Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 known ✓ | P08172 | 1/20 | 0.32 |
| ▸ | ADRA2A known ✓ | P08913 | 1/20 | 0.32 |
| ▸ | ACHE known ✓ | P22303 | 1/20 | 0.32 |
| ▸ | SLC6A2 known ✓ | P23975 | 1/20 | 0.32 |
| ▸ | ADRA1A known ✓ | P35348 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | GPR3 | P46089 | 1/20 | 0.34 |
| ▸ | BACE1 | P56817 | 1/20 | 0.34 |
| ▸ | NCF1 | P14598 | 1/20 | 0.34 |
| ▸ | DHODH | Q02127 | 2/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.33 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | APP | P05067 | 1/20 | 0.33 |
| ▸ | PRNP | P04156 | 1/20 | 0.33 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.33 |
| ▸ | ACP1 | P24666 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12390044 | 0.74 | CYP1A2 (0.41) | CYP1A2GPR3BACE1NCF1DHODH | |
| SCHEMBL4264698 | 0.71 | ADORA2A (0.42) | CYP1A2GPR3BACE1NCF1DHODH | |
| SCHEMBL26632761 | 0.70 | MAOA (0.38) | CYP1A2GPR3BACE1NCF1DHODH | |
| SCHEMBL3297357 | 0.67 | MAOA (0.42) | CYP1A2GPR3BACE1NCF1TSHR | |
| SCHEMBL3291837 | 0.67 | TDP1 (0.43) | CYP1A2GPR3BACE1NCF1TSHR | |
| SCHEMBL2600753 | 0.63 | CYP1A2 (0.60) | CYP1A2GPR3BACE1NCF1TSHR | |
| SCHEMBL7998749 | 0.63 | CYP1A2 (0.60) | CYP1A2GPR3NCF1KDM4EALDH1A1 | |
| SCHEMBL19148204 | 0.63 | MAOA (0.38) | CYP1A2BACE1NCF1KDM4EALDH1A1 | |
| SCHEMBL19301718 | 0.62 | CYP1A2 (0.46) | CYP1A2TSHRKDM4EALDH1A1POLB | |
| SCHEMBL22744405 | 0.62 | CYP1A2 (0.46) | CYP1A2TSHRKDM4EALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0399460-B1 | Silver halide photograpic material | FUJI PHOTO FILM CO LTD (JP) | 1996-10-23 | — | — | EP | disclosed |
| US-4996137-A | Developing exposed material containing emulsion layer with hexagonal tabular silver bromide core/shell grains | FUJI PHOTO FILM CO., LTD. (JP) | 1991-02-26 | — | — | US | disclosed |
| EP-0399460-A2 | Silver halide photograpic material | FUJI PHOTO FILM CO., LTD. (JP) | 1990-11-28 | — | — | EP | disclosed |
| EP-0303301-A2 | Silver halide photographic material | FUJI PHOTO FILM CO., LTD. (JP) | 1989-02-15 | — | — | EP | disclosed |