Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 | P08172 | 1/20 | 0.39 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.39 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9497662 | 1.00 | CHRM2 (0.39) | CHRM2CHRM5CHRM1HTTSMN1; SMN2 | |
| SCHEMBL9456951 | 0.80 | CHRM2 (0.64) | CHRM2CHRM5CHRM1 | |
| SCHEMBL9456947 | 0.80 | CHRM2 (0.64) | CHRM2CHRM5CHRM1 | |
| Hydrochloric Acid SCHEMBL9261270 | 0.79 | CHRM2 (0.62) | CHRM2CHRM5CHRM1 | |
| Hydrochloric Acid SCHEMBL9261273 | 0.79 | CHRM2 (0.62) | CHRM2CHRM5CHRM1 | |
| SCHEMBL9496824 | 0.77 | CHRNB2 (0.33) | CHRM2CHRM5CHRM1KMT2A | |
| SCHEMBL9009633 | 0.77 | CHRM2 (0.64) | CHRM2CHRM5CHRM1 | |
| SCHEMBL9009632 | 0.77 | CHRM2 (0.64) | CHRM2CHRM5CHRM1 | |
| SCHEMBL9009653 | 0.77 | CHRM2 (0.64) | CHRM2CHRM5CHRM1 | |
| SCHEMBL10390526 | 0.76 | CHRM2 (0.40) | CHRM2CHRM5CHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5532375-A | Process for preparing 1,2,5,6-tetrahydropyridin-3-carboxaldehyde oximes | ROUSSEL-UCLAF (FR) | 1996-07-02 | — | — | US | disclosed |
| US-5391754-A | Oximination a tetrahydropyridin-3-aldehyde, alkylation with a halides, salt formation | ROUSSEL UCLAF (FR) | 1995-02-21 | — | — | US | disclosed |
| US-5219872-A | Treating Alzheimer*s disease, memory disorders | ROUSSEL UCLAF (FR) | 1993-06-15 | — | — | US | disclosed |
| EP-0271798-B1 | O-SUBSTITUTED TETRAHYDROPYRIDINE OXIME CHOLINERGIC AGENTS | WARNER-LAMBERT COMPANY (US) | 1993-04-07 | — | — | EP | disclosed |
| EP-0239445-B1 | 1,2,5,6-TETRAHYDROPYRIDINE-3-CARBOXALDEHYDE OXIME DERIVATIVES, PROCESS FOR THEIR PREPARATION, COMPOSITIONS CONTAINING THEM AND THEIR USE AS MEDICINES | ROUSSEL-UCLAF (FR) | 1992-05-13 | — | — | EP | disclosed |
| US-4786648-A | ANALGESIC | WARNER-LAMBERT COMPANY (US) | 1988-11-22 | — | — | US | disclosed |
| EP-0271798-A2 | O-Substituted tetrahydropyridine oxime cholinergic agents | WARNER-LAMBERT COMPANY (US) | 1988-06-22 | — | — | EP | disclosed |
| EP-0239445-A2 | 1,2,5,6-Tetrahydropyridine-3-carboxaldehyde oxime derivatives, process for their preparation, compositions containing them and their use as medicines | ROUSSEL-UCLAF (FR) | 1987-09-30 | — | — | EP | disclosed |