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SCHEMBL9010583

SCHEMBL9010583

C=C1[C@H](O[Si](C)(C)C(C)(C)C)CC(=C/C=C2\CCC[C@]3(C)C([C@@H](C)CCC)CC[C@@H]23)C[C@H]1O[Si](C)(C)C(C)(C)C

nearest known ligand 0.58

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
▸ VDR P11473 9/20 0.57
▸ CYP24A1 Q07973 1/20 0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9010622 0.95 VDR (0.56) VDRCYP24A1
SCHEMBL14357531 0.95 VDR (0.56) VDRCYP24A1
SCHEMBL10820227 0.93 VDR (0.54) VDR
SCHEMBL14112577 0.93 VDR (0.54) VDR
SCHEMBL14489228 0.93 VDR (0.54) VDR
SCHEMBL13790494 0.92 VDR (0.56) VDRCYP24A1
SCHEMBL3865811 0.92 VDR (0.56) VDRCYP24A1
SCHEMBL9883792 0.91 VDR (0.54) VDRCYP24A1
SCHEMBL14409184 0.91 VDR (0.54) VDRCYP24A1
SCHEMBL14376135 0.91 VDR (0.54) VDRCYP24A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8188064-B2 Reducing cell differentiation of adipocyte; reducing body fat WISCONSIN ALUMNI RESEARCH FOUNDATION (US) 2012-05-29 — — US disclosed
US-7541348-B2 2-methylene-19-nor-(20S)-1α-hydroxy-trishomopregnacalciferol WISCONSIN ALUMNI RESEARCH FOUNDATION (US) 2009-06-02 — — US disclosed