Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 4/20 | 0.42 |
| ▸ | DNM1 | Q05193 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 6/20 | 0.35 |
| ▸ | FAAH | O00519 | 1/20 | 0.34 |
| ▸ | ZDHHC20 | Q5W0Z9 | 1/20 | 0.33 |
| ▸ | ZDHHC2 | Q9UIJ5 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.32 |
| ▸ | ADH1C | P00326 | 1/20 | 0.31 |
| ▸ | ADH1A | P07327 | 1/20 | 0.31 |
| ▸ | ADH4 | P08319 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL9681892 | 0.98 | DNM1 (0.46) | TSHRDNM1ALDH1A1KCNH2FAAH | |
| Bromide SCHEMBL11234061 | 0.98 | DNM1 (0.46) | TSHRDNM1ALDH1A1KCNH2FAAH | |
| Bromide SCHEMBL11245109 | 0.98 | DNM1 (0.46) | TSHRDNM1ALDH1A1KCNH2FAAH | |
| Bromide SCHEMBL11244279 | 0.98 | DNM1 (0.46) | TSHRDNM1ALDH1A1KCNH2FAAH | |
| SCHEMBL788690 | 0.98 | TSHR (0.44) | TSHRDNM1ALDH1A1KCNH2FAAH | |
| SCHEMBL14812559 | 0.98 | TSHR (0.44) | TSHRDNM1ALDH1A1KCNH2FAAH | |
| SCHEMBL11043940 | 0.95 | TSHR (0.48) | TSHRDNM1ALDH1A1KCNH2FAAH | |
| SCHEMBL7167469 | 0.95 | TSHR (0.48) | TSHRDNM1ALDH1A1KCNH2FAAH | |
| SCHEMBL4755851 | 0.95 | TSHR (0.48) | TSHRDNM1ALDH1A1KCNH2FAAH | |
| SCHEMBL9567939 | 0.95 | TSHR (0.48) | TSHRDNM1ALDH1A1KCNH2FAAH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5518585-A | Neutral sizing agent for base paper stuff with the use of cationic plastics dispersions | HOECHST AKTIENGESELLSCHAFT (DE) | 1996-05-21 | — | — | US | disclosed |