Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2 | P00734 | 7/20 | 0.39 |
| ▸ | ACE | P12821 | 2/20 | 0.36 |
| ▸ | ACE2 | Q9BYF1 | 2/20 | 0.36 |
| ▸ | PRSS1 | P07477 | 4/20 | 0.36 |
| ▸ | CMA1 | P23946 | 1/20 | 0.35 |
| ▸ | XIAP | P98170 | 4/20 | 0.35 |
| ▸ | PRSS2 | P07478 | 3/20 | 0.34 |
| ▸ | PRSS3 | P35030 | 3/20 | 0.34 |
| ▸ | TMPRSS11D | O60235 | 3/20 | 0.34 |
| ▸ | F10 | P00742 | 1/20 | 0.34 |
| ▸ | PLG | P00747 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9011972 | 1.00 | F2 (0.39) | F2ACEACE2PRSS1CMA1 | |
| SCHEMBL9012287 | 0.86 | F2 (0.39) | F2PRSS1CMA1XIAPPRSS2 | |
| SCHEMBL9012276 | 0.86 | F2 (0.39) | F2PRSS1CMA1XIAPPRSS2 | |
| SCHEMBL9011985 | 0.85 | F2 (0.43) | F2ACEACE2PRSS1CMA1 | |
| SCHEMBL9012394 | 0.85 | F2 (0.39) | F2PRSS1CMA1XIAPPRSS2 | |
| SCHEMBL9012387 | 0.85 | F2 (0.39) | F2PRSS1CMA1XIAPPRSS2 | |
| SCHEMBL9012283 | 0.83 | F2 (0.48) | F2PRSS1CMA1XIAPPRSS2 | |
| SCHEMBL9012270 | 0.83 | F2 (0.48) | F2PRSS1CMA1XIAPPRSS2 | |
| SCHEMBL9012093 | 0.83 | F2 (0.38) | F2PRSS1CMA1XIAPPRSS2 | |
| SCHEMBL9012086 | 0.83 | F2 (0.38) | F2PRSS1CMA1XIAPPRSS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0743320-A2 | Acyl guanidine and amidine prodrugs | BRISTOL-MYERS SQUIBB COMPANY (US) | 1996-11-20 | — | — | EP | claimed |
| EP-0743320-A2 | Acyl guanidine and amidine prodrugs | BRISTOL-MYERS SQUIBB COMPANY (US) | 1996-11-20 | — | — | EP | disclosed |