Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2 | P00734 | 8/20 | 0.50 |
| ▸ | CMA1 | P23946 | 2/20 | 0.42 |
| ▸ | ACE | P12821 | 1/20 | 0.41 |
| ▸ | PRSS1 | P07477 | 4/20 | 0.41 |
| ▸ | PRSS2 | P07478 | 3/20 | 0.41 |
| ▸ | PRSS3 | P35030 | 3/20 | 0.41 |
| ▸ | F10 | P00742 | 3/20 | 0.40 |
| ▸ | TMPRSS11D | O60235 | 3/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9012003 | 1.00 | F2 (0.50) | F2CMA1ACEPRSS1PRSS2 | |
| SCHEMBL9012556 | 0.90 | ACE (0.46) | F2CMA1ACEPRSS1PRSS2 | |
| SCHEMBL9012560 | 0.90 | ACE (0.46) | F2CMA1ACEPRSS1PRSS2 | |
| SCHEMBL9012129 | 0.87 | F2 (0.46) | F2CMA1ACETMPRSS11D | |
| SCHEMBL9012557 | 0.87 | F2 (0.46) | F2CMA1PRSS1PRSS2PRSS3 | |
| SCHEMBL9012113 | 0.87 | F2 (0.46) | F2CMA1ACETMPRSS11D | |
| SCHEMBL9012549 | 0.87 | F2 (0.46) | F2CMA1PRSS1PRSS2PRSS3 | |
| SCHEMBL9012346 | 0.86 | F2 (0.51) | F2CMA1PRSS1PRSS2PRSS3 | |
| SCHEMBL9012355 | 0.86 | F2 (0.51) | F2CMA1PRSS1PRSS2PRSS3 | |
| SCHEMBL9012023 | 0.86 | F2 (0.44) | F2CMA1ACEPRSS1PRSS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0743320-A2 | Acyl guanidine and amidine prodrugs | BRISTOL-MYERS SQUIBB COMPANY (US) | 1996-11-20 | — | — | EP | claimed |
| EP-0743320-A2 | Acyl guanidine and amidine prodrugs | BRISTOL-MYERS SQUIBB COMPANY (US) | 1996-11-20 | — | — | EP | disclosed |