Known targets — ChEMBL curated mechanism
KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2
The experimentally established mechanism targets of Pyrazole. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Pyrazole SCHEMBL27553902 | 0.97 | — | — | |
| Pyrazole SCHEMBL27984995 | 0.93 | — | — | |
| Pyrazole SCHEMBL25401896 | 0.90 | — | — | |
| Pyrazole SCHEMBL26122185 | 0.88 | — | — | |
| Pyrazole SCHEMBL27617303 | 0.87 | NQO2 (0.33) | — | |
| Pyrazole SCHEMBL18227431 | 0.86 | — | — | |
| Pyrazole SCHEMBL27903082 | 0.84 | — | — | |
| Pyrazole SCHEMBL1129000 | 0.84 | — | — | |
| Pyrazole SCHEMBL1724037 | 0.83 | — | — | |
| Pyrazole SCHEMBL5664483 | 0.83 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106008274-A | Preparation method of N,N'-dicyclohexylurea | 绍兴文理学院 | 2016-10-12 | — | — | CN | claimed |
| EP-0743320-A2 | Acyl guanidine and amidine prodrugs | BRISTOL-MYERS SQUIBB COMPANY (US) | 1996-11-20 | — | — | EP | claimed |
| EP-3430000-B1 | PYRIMIDINES AND VARIANTS THEREOF, AND USES THEREFOR | AFFERENT PHARMACEUTICALS INC (US) | 2022-12-28 | — | — | EP | disclosed |
| US-10822311-B2 | Pyrimidines and variants thereof, and uses therefor | Afferent Pharmaceuticals, Inc. (US) | 2020-11-03 | — | — | US | disclosed |
| EP-3430000-A1 | PYRIMIDINES AND VARIANTS THEREOF, AND USES THEREFOR | Afferent Pharmaceuticals Inc. (US) | 2019-01-23 | — | — | EP | disclosed |
| CN-108834412-A | Pyrimidine and its variant, and application thereof | 传入制药公司 | 2018-11-16 | — | — | CN | disclosed |
| CN-103635472-B | Serine/threonine kinase inhibitor | 阵列生物制药公司 | 2018-01-12 | — | — | CN | disclosed |
| WO-2017160569-A1 | PYRIMIDINES AND VARIANTS THEREOF, AND USES THEREFOR | AFFERENT PHARMACEUTICALS INC. (US) | 2017-09-21 | — | — | WO | disclosed |
| US-9301974-B2 | Methods and compositions for selectively removing potassium ion from the gastrointestinal tract of a mammal | RELYPSA, INC. (US) | 2016-04-05 | — | — | US | disclosed |
| CN-103635472-A | Serine/threonine kinase inhibitors | ARRAY BIOPHARMA INC | 2014-03-12 | — | — | CN | disclosed |
| US-20140044804-A1 | METHODS AND COMPOSITIONS FOR SELECTIVELY REMOVING POTASSIUM ION FROM THE GASTROINTESTINAL TRACT OF A MAMMAL | RELYPSA, INC. (US) | 2014-02-13 | — | — | US | disclosed |
| CN-1184473-A | 6-Hydroxyamide-Dihydropyran Derivatives | BIOTA SCIENT MANAGEMENT (AU) | 1998-06-10 | — | — | CN | disclosed |