Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2 | P00734 | 4/20 | 0.55 |
| ▸ | CHRM3 | P20309 | 5/20 | 0.52 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.48 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.48 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.48 |
| ▸ | TMPRSS11D | O60235 | 2/20 | 0.47 |
| ▸ | BDKRB2 | P30411 | 1/20 | 0.47 |
| ▸ | BDKRB1 | P46663 | 1/20 | 0.47 |
| ▸ | F10 | P00742 | 1/20 | 0.46 |
| ▸ | PLG | P00747 | 1/20 | 0.46 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.46 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.46 |
| ▸ | CMA1 | P23946 | 1/20 | 0.45 |
| ▸ | ACE | P12821 | 6/20 | 0.43 |
| ▸ | ACE2 | Q9BYF1 | 4/20 | 0.43 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL9012341 | 0.96 | CHRM3 (0.57) | F2CHRM3CHRM2CHRM4CHRM1 | |
| SCHEMBL9087480 | 0.90 | TMPRSS11D (0.57) | F2CHRM3CHRM2CHRM4CHRM1 | |
| SCHEMBL7589201 | 0.89 | F2 (0.70) | F2PRSS1 | |
| SCHEMBL9073832 | 0.86 | F2 (0.54) | F2TMPRSS11DCMA1ACEPRSS1 | |
| SCHEMBL7346744 | 0.86 | F2 (0.54) | F2TMPRSS11DF10PLGPRSS1 | |
| SCHEMBL7346760 | 0.86 | F2 (0.54) | F2TMPRSS11DCMA1ACEPRSS1 | |
| SCHEMBL9086574 | 0.85 | F2 (0.51) | F2TMPRSS11DF10PLGCMA1 | |
| SCHEMBL9086586 | 0.85 | F2 (0.51) | F2CMA1ACEACE2PRSS1 | |
| SCHEMBL7339322 | 0.84 | F2 (0.51) | F2TMPRSS11DF10PLGCMA1 | |
| SCHEMBL9073567 | 0.84 | F2 (0.51) | F2TMPRSS11DF10PLGPRSS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0743320-A2 | Acyl guanidine and amidine prodrugs | BRISTOL-MYERS SQUIBB COMPANY (US) | 1996-11-20 | — | — | EP | disclosed |
| US-5561146-A | Modified guanidino and amidino thrombin inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 1996-10-01 | — | — | US | disclosed |