Lysepsin A

Lysepsin A

SCHEMBL9012919

NCCCC[C@@H](C(=O)O)N(CCCl)CCCl

nearest known ligand 0.46

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GSR P00390 1/20 0.46
RNPEP Q9H4A4 1/20 0.44
CPB2 Q96IY4 7/20 0.41
FOLH1 Q04609 1/20 0.36
CYP2D6 P10635 1/20 0.33
NFKB1 P19838 1/20 0.33
CPB1 P15086 1/20 0.33
BLM P54132 1/20 0.32
NPSR1 Q6W5P4 1/20 0.32
MEN1 O00255 1/20 0.32
ALDH1A1 P00352 1/20 0.32
PLG P00747 1/20 0.32
LMNA P02545 1/20 0.32
THRB P10828 1/20 0.32
ALOX15 P16050 1/20 0.32
SLC6A2 P23975 1/20 0.32
RECQL P46063 1/20 0.32
SLC6A3 Q01959 1/20 0.32
KMT2A Q03164 1/20 0.32
EPOR P19235 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6859332 0.87 GSR (0.50) GSRRNPEPCPB2FOLH1CYP2D6
SCHEMBL6859337 0.87 GSR (0.50) GSRRNPEPCPB2FOLH1CYP2D6
SCHEMBL4689784 0.84 GSR (0.47) GSRRNPEPCPB2FOLH1CYP2D6
SCHEMBL4689786 0.84 GSR (0.47) GSRRNPEPCPB2FOLH1CYP2D6
SCHEMBL4300233 0.82 GSR (0.46) GSRRNPEPCPB2FOLH1NOD1
SCHEMBL4300231 0.82 GSR (0.46) GSRRNPEPCPB2FOLH1NOD1
SCHEMBL17872154 0.81 CPB2 (0.44) GSRRNPEPCPB2FOLH1CYP2D6
SCHEMBL17872153 0.81 CPB2 (0.44) GSRRNPEPCPB2FOLH1CYP2D6
SCHEMBL11578897 0.79 GSR (0.50) GSRRNPEPCPB2FOLH1CYP2D6
SCHEMBL11578907 0.79 GSR (0.50) GSRRNPEPCPB2FOLH1CYP2D6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0580642-B1 AMINOACYL DERIVATIVES OF GEM-DIPHOSPHONIC ACIDS, A PROCESS FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM BOEHRINGER MANNHEIM ITALIA (IT) 1996-11-06 EP disclosed
EP-0593437-A1 GEM-DIPHOSPHONIC ACIDS, A PROCESS FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM. BOEHRINGER MANNHEIM ITALIA (IT) 1994-04-27 EP disclosed
EP-0580642-A1 AMINOACYL DERIVATIVES OF GEM-DIPHOSPHONIC ACIDS, A PROCESS FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM. BOEHRINGER MANNHEIM ITALIA (IT) 1994-02-02 EP disclosed
WO-1992018512-A1 AMINOACYL DERIVATIVES OF GEM-DIPHOSPHONIC ACIDS, A PROCESS FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM BOEHRINGER MANNHEIM ITALIA S.P.A. (IT) 1992-10-29 WO disclosed