Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SSTR3 | P32745 | 1/20 | 0.49 |
| ▸ | GHSR | Q92847 | 1/20 | 0.42 |
| ▸ | FKBP4 | Q02790 | 1/20 | 0.42 |
| ▸ | HDAC3 | O15379 | 5/20 | 0.41 |
| ▸ | HDAC11 | Q96DB2 | 5/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 5/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 4/20 | 0.41 |
| ▸ | HDAC10 | Q969S8 | 4/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 4/20 | 0.41 |
| ▸ | CTSC | P53634 | 1/20 | 0.41 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.41 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.41 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.41 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.41 |
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.40 |
| ▸ | REN | P00797 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7047405 | 1.00 | SSTR3 (0.49) | SSTR3GHSRFKBP4HDAC3HDAC11 | |
| Hydrochloric Acid SCHEMBL3277643 | 0.99 | SSTR3 (0.48) | SSTR3GHSRFKBP4HDAC3HDAC11 | |
| Edetic Acid SCHEMBL8001970 | 0.94 | SSTR3 (0.44) | SSTR3GHSRFKBP4HDAC3HDAC11 | |
| SCHEMBL5673516 | 0.92 | HDAC3 (0.42) | SSTR3HDAC3HDAC11HDAC6HDAC1 | |
| Hydrochloric Acid SCHEMBL10380405 | 0.91 | HDAC3 (0.42) | SSTR3HDAC3HDAC11HDAC6HDAC1 | |
| Hydrochloric Acid SCHEMBL9543019 | 0.91 | HDAC3 (0.42) | SSTR3HDAC3HDAC11HDAC6HDAC1 | |
| 4-Nitroaniline SCHEMBL27616115 | 0.89 | MAPK8 (0.43) | SSTR3GHSRCTSCMAPK8MAPK9 | |
| Hydrochloric Acid SCHEMBL29422207 | 0.87 | SSTR3 (0.49) | SSTR3GHSR | |
| SCHEMBL1723853 | 0.87 | CTSC (0.53) | SSTR3FKBP4CTSCUSP30MEN1 | |
| SCHEMBL8478585 | 0.87 | FURIN (0.46) | GHSRHDAC3HDAC11HDAC6HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240132573-A1 | MODIFIED SERPINS FOR THE TREATMENT OF BRADYKININ-MEDIATED DISEASE | PRECLINICS GESELLSCHAFT FÜR PRÄKLINISCHE FORSCHUNG MBH (DE) | 2024-04-25 | — | — | US | disclosed |
| US-11851474-B2 | Modified serpins for the treatment of bradykinin-mediated disease | PRECLINICS GESELLSCHAFT FÜR PRÄKLINISCHE FORSCHUNG MBH (DE) | 2023-12-26 | — | — | US | disclosed |
| EP-3585808-B1 | MODIFIED SERPINS FOR THE TREATMENT OF BRADYKININ-MEDIATED DISEASE | PRECLINICS GES FUER PRAEKLINISCHE FORSCHUNG MBH (DE) | 2021-11-10 | — | — | EP | disclosed |
| WO-2018154044-A1 | MODIFIED SERPINS FOR THE TREATMENT OF BRADYKININ-MEDIATED DISEASE | UMC UTRECHT HOLDING B.V. (NL) | 2018-08-30 | — | — | WO | disclosed |
| EP-2697652-B1 | DIAGNOSIS AND TREATMENT OF ANGIOEDEMA | UNIV GRENOBLE 1 (FR) | 2016-09-14 | — | — | EP | disclosed |
| US-20140051099-A1 | DIAGNOSIS AND TREATMENT OF ANGIOEDEMA | CENTRE HOSPITALIER UNIVERSITAIRE DE GRENOBLE (FR) | 2014-02-20 | — | — | US | disclosed |
| EP-2697652-A1 | DIAGNOSIS AND TREATMENT OF ANGIOEDEMA | Universite Joseph Fourier (Grenoble 1) (FR) | 2014-02-19 | — | — | EP | disclosed |
| WO-2012140372-A1 | DIAGNOSIS AND TREATMENT OF ANGIOEDEMA | UNIVERSITE JOSEPH FOURIER (GRENOBLE 1) (FR) | 2012-10-18 | — | — | WO | disclosed |
| US-5500349-A | Blood-coagulation factor XIIA β monoclonal antibody and immunoassay | COAGEN LIMITED (GB) | 1996-03-19 | — | — | US | disclosed |
| EP-0455707-B1 | BLOOD-COAGULATION FACTOR BETAXIIa MONOCLONAL ANTIBODY AND IMMUNOASSAY | COAGEN LTD (GB) | 1995-04-26 | — | — | EP | disclosed |
| US-5118793-A | Substitution of arginine at position 44 for leucine; antithrombin | WASHINGTON UNIVERSITY (US) | 1992-06-02 | — | — | US | disclosed |
| US-5102995-A | Anticoagulant | WASHINGTON UNIVERSITY (US) | 1992-04-07 | — | — | US | disclosed |
| EP-0455707-A1 | BLOOD-COAGULATION FACTOR XIIa -g(b) MONOCLONAL ANTIBODY AND IMMUNOASSAY. | COAGEN LTD (GB) | 1991-11-13 | — | — | EP | disclosed |
| WO-1990008835-A1 | BLOOD-COAGULATION FACTOR XIIa β MONOCLONAL ANTIBODY AND IMMUNOASSAY | COAGEN LIMITED (GB) | 1990-08-09 | — | — | WO | disclosed |
| EP-0259857-A2 | Method of assaying physiologically active substances | NIPPON ZOKI PHARMACEUTICAL CO. LTD. (JP) | 1988-03-16 | — | — | EP | disclosed |
| US-4610879-A | Fibrinolytic enzyme from snake vernom | UNIVERSITY OF SOUTHERN CALIFORNIA (US) | 1986-09-09 | — | — | US | disclosed |
| US-4308202-A | Prolylphenylalanylarginine derivatives, process for producing same and method for measuring activity of enzymes using same | TORII & CO., LTD. (JP) | 1981-12-29 | — | — | US | disclosed |