SCHEMBL5673516

SCHEMBL5673516

N=C(N)NCCC[C@H](NC(=O)[C@@H]1CCCN1)C(=O)Nc1ccc([N+](=O)[O-])cc1

nearest known ligand 0.42

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
▸ HDAC3 O15379 12/20 0.42
▸ HDAC11 Q96DB2 12/20 0.42
▸ HDAC6 Q9UBN7 12/20 0.42
▸ HDAC1 Q13547 11/20 0.42
▸ HDAC2 Q92769 11/20 0.42
▸ HDAC10 Q969S8 11/20 0.42
▸ HDAC8 Q9BY41 11/20 0.42
▸ PDF Q9HBH1 1/20 0.42
▸ NCOR2 Q9Y618 3/20 0.38
▸ NAMPT P43490 1/20 0.38
▸ HDAC4 P56524 1/20 0.38
▸ HDAC7 Q8WUI4 1/20 0.38
▸ HDAC9 Q9UKV0 1/20 0.38
▸ HDAC5 Q9UQL6 1/20 0.38
▸ TERT O14746 1/20 0.36
▸ SSTR3 P32745 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL9543019 0.99 HDAC3 (0.42) HDAC3HDAC11HDAC6HDAC1HDAC2
Hydrochloric Acid SCHEMBL10380405 0.99 HDAC3 (0.42) HDAC3HDAC11HDAC6HDAC1HDAC2
SCHEMBL7047405 0.92 SSTR3 (0.49) HDAC3HDAC11HDAC6HDAC1HDAC2
SCHEMBL9013073 0.92 SSTR3 (0.49) HDAC3HDAC11HDAC6HDAC1HDAC2
Hydrochloric Acid SCHEMBL3277643 0.91 SSTR3 (0.48) HDAC3HDAC11HDAC6HDAC1HDAC2
SCHEMBL8532855 0.90 KEAP1 (0.42) HDAC3HDAC11HDAC6HDAC1HDAC2
SCHEMBL30686001 0.88 MAPK8 (0.45) HDAC3HDAC11HDAC6HDAC1HDAC2
SCHEMBL7761782 0.87 PDF (0.55) HDAC3HDAC11HDAC6HDAC1HDAC2
Edetic Acid SCHEMBL8001970 0.86 SSTR3 (0.44) HDAC3HDAC11HDAC6HDAC1HDAC2
Nitrobenzene SCHEMBL29006904 0.86 CTSC (0.41) HDAC3HDAC11HDAC6HDAC1HDAC2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 70 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-113913491-B Method for measuring protein C activity, reagent for measuring protein C activity, and method for producing the same 青岛大学附属医院 2023-09-29 — — CN claimed
CN-110714051-B Protein C activity determination kit 迈克生物股份有限公司 2023-04-07 — — CN claimed
JP-59102400-A — — None — — JP disclosed
EP-4037687-B1 BENZOXAZINONE COMPOUNDS AS KLK5/7 DUAL INHIBITORS MOLECULAR SKIN THERAPEUTICS INC (US) 2025-10-29 — — EP disclosed
EP-3812772-B1 METHOD FOR DIAGNOSING FIBRINOLYTIC INSUFFICIENCY RELATED TO NEUTROPHIL EXTRACELLULAR TRAPS HOPITAUX UNIV DE STRASBOURG HUS (FR) 2025-02-19 — — EP disclosed
CN-114615984-B Benzoxazinone compounds as dual KLK5/7 inhibitors 分子皮肤治疗公司 2025-02-07 — — CN disclosed
US-20240288446-A1 METHOD FOR DIAGNOSING FIBRINOLYTIC INSUFFICIENCY RELATED TO NEUTROPHIL EXTRACELLULAR TRAPS HÔPITAUX UNIVERSITAIRES DE STRASBOURG (FR) 2024-08-29 — — US disclosed
EP-4347641-A1 PLASMA FRACTIONATION BY CONTINUOUS EXTRACTION CSL Behring AG (CH) 2024-04-10 — — EP disclosed
CN-113913491-B Method for measuring protein C activity, reagent for measuring protein C activity, and method for producing the same 青岛大学附属医院 2023-09-29 — — CN disclosed
US-20230138003-A1 DIHYDROINDOLIZINONE DERIVATIVE ONO PHARMACEUTICAL CO., LTD. (JP) 2023-05-04 — — US disclosed
CN-110714051-B Protein C activity determination kit 迈克生物股份有限公司 2023-04-07 — — CN disclosed
EP-0863755-A1 ANTITHROMBOTIC DIAMINES ELI LILLY AND COMPANY (US) 1998-09-16 — — EP disclosed
WO-1997049404-A1 ANTICOAGULANT AGENTS ELI LILLY AND COMPANY (US) 1997-12-31 — — WO disclosed
WO-1997025033-A1 ANTITHROMBOTIC DIAMINES ELI LILLY AND COMPANY (US) 1997-07-17 — — WO disclosed
EP-0676964-A1 NITROSYLATION OF PROTEIN SH GROUPS AND AMINO ACID RESIDUES AS A THERAPEUTIC MODALITY BRIGHAM AND WOMEN'S HOSPITAL (US) 1995-10-18 — — EP disclosed
EP-0676964-A4 NITROSYLATION OF PROTEIN SH GROUPS AND AMINO ACID RESIDUES AS A THERAPEUTIC MODALITY. BRIGHAM & WOMENS HOSPITAL (US) 1995-08-10 — — EP disclosed
WO-1993009806-A1 NITROSYLATION OF PROTEIN SH GROUPS AND AMINO ACID RESIDUES AS A THERAPEUTIC MODALITY BRIGHAM AND WOMEN'S HOSPITAL (US) 1993-05-27 — — WO disclosed
EP-0175729-A1 MOLECULAR FILM SUPPORTED FROM A FIBRIN NETWORK ENABLING THE SELECTIVE RETENTION, AT ITS SURFACE, OF THE TISSULAR PLASMINOGENE ACTIVATOR AND APPLICATIONS DERIVED THEREFROM INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) (FR) 1986-04-02 — — EP disclosed
WO-1985004425-A1 MOLECULAR FILM SUPPORTED FROM A FIBRIN NETWORK ENABLING THE SELECTIVE RETENTION, AT ITS SURFACE, OF THE TISSULAR PLASMINOGENE ACTIVATOR AND APPLICATIONS DERIVED THEREFROM INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE M (FR) 1985-10-10 — — WO disclosed
JP-S59102400-A METHOD FOR MEASURING BIOLOGICAL ACTIVITY OF ANTITHROMBIN III FUJIMOTO DAIAGUNOSUTEITSUKUSU:KK 1984-06-13 — — JP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230138003-A1 DIHYDROINDOLIZINONE DERIVATIVE TFPI, F2, TFPI2 HDAC3 1017/4885HDAC11 506/4885HDAC6 999/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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