SCHEMBL9013089

SCHEMBL9013089

N[C@@H](Cc1ccc(N(CCCl)CCCl)cc1)C(=O)N1CCC[C@H]1C(=O)NCCCCC(O)(P(=O)(O)O)P(=O)(O)O

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 3/20 0.41
OPRM1 P35372 3/20 0.41
ALDH1A1 P00352 2/20 0.41
ALOX15 P16050 2/20 0.41
SMN1; SMN2 Q16637 2/20 0.41
HIF1A Q16665 2/20 0.41
ABCB11 O95342 1/20 0.41
CHRM2 P08172 1/20 0.41
ADRA2A P08913 1/20 0.41
CHRM1 P11229 1/20 0.41
ACHE P22303 1/20 0.41
PTGS1 P23219 1/20 0.41
DRD3 P35462 1/20 0.41
SLC6A3 Q01959 1/20 0.41
KCNH2 Q12809 1/20 0.41
TDP1 Q9NUW8 1/20 0.41
CYP1A2 P05177 1/20 0.41
NFKB1 P19838 1/20 0.41
THPO P40225 1/20 0.41
KDM4E B2RXH2 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9012824 0.94 CYP3A4 (0.43) CYP3A4OPRM1ALDH1A1ALOX15SMN1; SMN2
SCHEMBL9013076 0.84 FKBP1A (0.43) ALDH1A1SMN1; SMN2HIF1ANFKB1THPO
SCHEMBL9013907 0.82 CYP3A4 (0.47) CYP3A4OPRM1ALDH1A1ALOX15SMN1; SMN2
Hydrochloric Acid SCHEMBL9013935 0.81 CYP3A4 (0.46) CYP3A4OPRM1ALDH1A1ALOX15SMN1; SMN2
Hydrochloric Acid SCHEMBL8983358 0.81 CYP3A4 (0.51) CYP3A4OPRM1ALDH1A1ALOX15SMN1; SMN2
SCHEMBL8983317 0.81 CYP3A4 (0.51) CYP3A4OPRM1ALDH1A1ALOX15SMN1; SMN2
SCHEMBL9012950 0.80 CYP3A4 (0.46) CYP3A4OPRM1ALDH1A1ALOX15SMN1; SMN2
SCHEMBL9012892 0.79 FKBP1A (0.42) ALDH1A1SMN1; SMN2HIF1ANFKB1THPO
Hydrochloric Acid SCHEMBL9012993 0.79 CYP3A4 (0.45) CYP3A4OPRM1ALDH1A1ALOX15SMN1; SMN2
SCHEMBL8983269 0.79 CYP3A4 (0.53) CYP3A4OPRM1ALDH1A1ALOX15SMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0580642-B1 AMINOACYL DERIVATIVES OF GEM-DIPHOSPHONIC ACIDS, A PROCESS FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM BOEHRINGER MANNHEIM ITALIA (IT) 1996-11-06 EP disclosed
US-5446187-A Aminoacyl derivatives of gem-diphosphonic acids, a process for the preparation thereof and pharmaceutical compositions containing them BOEHRINGER MANNHEIM ITALIA S.P.A. (IT) 1995-08-29 US disclosed
WO-1992018512-A1 AMINOACYL DERIVATIVES OF GEM-DIPHOSPHONIC ACIDS, A PROCESS FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM BOEHRINGER MANNHEIM ITALIA S.P.A. (IT) 1992-10-29 WO disclosed