Known targets — ChEMBL curated mechanism
CHRM1DRD2DRD3DRD4HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HTR2APDE3ASIGMAR1
The experimentally established mechanism targets of Lactic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 known ✓ | P11229 | 1/20 | 0.52 |
| ▸ | HTR2A known ✓ | P28223 | 1/20 | 0.52 |
| ▸ | HRH1 known ✓ | P35367 | 1/20 | 0.52 |
| ▸ | DRD3 known ✓ | P35462 | 1/20 | 0.52 |
| ▸ | HDAC1 known ✓ | Q13547 | 1/20 | 0.52 |
| ▸ | HDAC2 known ✓ | Q92769 | 1/20 | 0.52 |
| ▸ | TP53 | P04637 | 1/20 | 0.58 |
| ▸ | AKR1A1 | P14550 | 1/20 | 0.52 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.52 |
| ▸ | HTR2C | P28335 | 1/20 | 0.52 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.52 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.52 |
| ▸ | GPR84 | Q9NQS5 | 3/20 | 0.43 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.43 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.40 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.40 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.40 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.40 |
| ▸ | GRIK2 | Q13002 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Succinic Acid SCHEMBL28829567 | 0.91 | TP53 (0.48) | TP53CHRM1AKR1A1CHRM3HTR2A | |
| SCHEMBL28191657 | 0.90 | CHRM1 (0.52) | TP53CHRM1AKR1A1CHRM3HTR2A | |
| Adipic Acid SCHEMBL31152667 | 0.87 | FFAR4 (0.53) | TP53TDP1GPR84FFAR1TSHR | |
| Bicarbonate SCHEMBL10590002 | 0.86 | HDAC1 (0.52) | CHRM1AKR1A1CHRM3HTR2AHTR2C | |
| Bicarbonate SCHEMBL14562444 | 0.86 | HDAC1 (0.52) | CHRM1AKR1A1CHRM3HTR2AHTR2C | |
| SCHEMBL1171047 | 0.85 | TDP1 (0.48) | TP53CHRM1AKR1A1CHRM3HTR2A | |
| SCHEMBL3504285 | 0.84 | CHRM1 (0.40) | TP53CHRM1AKR1A1CHRM3HTR2A | |
| Lactic Acid SCHEMBL9473453 | 0.84 | CHRM1 (0.43) | TP53CHRM1AKR1A1CHRM3HTR2A | |
| Acetic Acid SCHEMBL11353075 | 0.83 | CHRM1 (0.50) | CHRM1AKR1A1CHRM3HTR2AHTR2C | |
| Oxalic Acid SCHEMBL28869438 | 0.83 | CHRM1 (0.50) | CHRM1AKR1A1CHRM3HTR2AHTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0515231-B1 | Biodegradable fish bait made of polyester-polyurethanes | HAMPSHIRE CHEMICAL CORP (US) | 1996-11-13 | — | — | EP | disclosed |
| US-5270044-A | Polyesterurethane, polyoxyethylene glycol, CMC | HAMPSHIRE CHEMICAL CORP. (US) | 1993-12-14 | — | — | US | disclosed |
| US-5266323-A | Polyurethanes | HAMPSHIRE CHEMICAL CORP. (US) | 1993-11-30 | — | — | US | disclosed |
| EP-0515231-A2 | Biodegradable fish bait made of polyester-polyurethanes | HAMPSHIRE CHEMICAL CORPORATION (US) | 1992-11-25 | — | — | EP | disclosed |