Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.66 |
| ▸ | MEN1 | O00255 | 3/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.59 |
| ▸ | MAPT | P10636 | 6/20 | 0.52 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.50 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.45 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | NEK2 | P51955 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4509698 | 0.80 | LMNA (0.73) | LMNAMEN1KMT2ASMN1; SMN2MAPT | |
| SCHEMBL25262380 | 0.79 | MAPT (0.66) | LMNAMEN1KMT2ASMN1; SMN2MAPT | |
| SCHEMBL13722871 | 0.78 | NOTUM (0.62) | LMNAMEN1KMT2ASMN1; SMN2MAPT | |
| SCHEMBL24156124 | 0.76 | ADORA2A (0.39) | LMNAPDE3BPDE3A | |
| SCHEMBL25194853 | 0.76 | LMNA (0.65) | LMNAMEN1KMT2ASMN1; SMN2MAPT | |
| SCHEMBL4098087 | 0.76 | MEN1 (0.66) | LMNAMEN1KMT2ASMN1; SMN2MAPT | |
| SCHEMBL31038214 | 0.76 | LMNA (0.65) | LMNAMEN1KMT2ASMN1; SMN2MAPT | |
| SCHEMBL25153864 | 0.76 | LMNA (0.51) | LMNAMEN1KMT2ASMN1; SMN2KDM4E | |
| SCHEMBL5759922 | 0.76 | MAPT (0.62) | LMNAMEN1KMT2ASMN1; SMN2MAPT | |
| SCHEMBL22807107 | 0.76 | SMN1; SMN2 (0.55) | LMNAMEN1KMT2ASMN1; SMN2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2441755-A1 | Pyridine- and isoquinoline-derivatives as Syk and JAK kinase inhibitors | Almirall, S.A. (ES) | 2012-04-18 | — | — | EP | disclosed |
| WO-2012041476-A1 | PYRIDINE AND ISOQUINOLINE DERIVATIVES AS SYK- AND JAK-KINASE INHIBITORS | ALMIRALL, S.A. (ES) | 2012-04-05 | — | — | WO | disclosed |