Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Angiotensin Ii. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGTR1 known ✓ | P30556 | 3/20 | 0.69 |
| ▸ | AGTR2 | P50052 | 8/20 | 0.69 |
| ▸ | C5AR1 | P21730 | 2/20 | 0.60 |
| ▸ | EPHA2 | P29317 | 2/20 | 0.56 |
| ▸ | F2 | P00734 | 4/20 | 0.56 |
| ▸ | APLNR | P35414 | 1/20 | 0.55 |
| ▸ | NTSR2 | O95665 | 2/20 | 0.54 |
| ▸ | NTSR1 | P30989 | 2/20 | 0.54 |
| ▸ | SORT1 | Q99523 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Angiotensin Ii SCHEMBL22125774 | 1.00 | AGTR2 (0.69) | AGTR2AGTR1C5AR1EPHA2F2 | |
| Angiotensin Ii SCHEMBL29757879 | 1.00 | AGTR2 (0.69) | AGTR2AGTR1C5AR1EPHA2F2 | |
| Angiotensin Ii SCHEMBL9013957 | 1.00 | AGTR2 (0.69) | AGTR2AGTR1C5AR1EPHA2F2 | |
| SCHEMBL30445863 | 1.00 | AGTR2 (0.69) | AGTR2AGTR1C5AR1EPHA2F2 | |
| Angiotensin Ii SCHEMBL28966994 | 0.99 | AGTR2 (0.68) | AGTR2AGTR1C5AR1EPHA2F2 | |
| Angiotensin Ii SCHEMBL30960106 | 0.99 | AGTR2 (0.68) | AGTR2AGTR1C5AR1EPHA2F2 | |
| SCHEMBL24454648 | 0.98 | AGTR2 (0.69) | AGTR2AGTR1C5AR1EPHA2F2 | |
| SCHEMBL29701256 | 0.97 | AGTR2 (0.65) | AGTR2AGTR1C5AR1EPHA2F2 | |
| SCHEMBL29359023 | 0.97 | AGTR2 (0.66) | AGTR2AGTR1C5AR1EPHA2F2 | |
| SCHEMBL29976758 | 0.97 | AGTR2 (0.65) | AGTR2AGTR1C5AR1EPHA2F2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5571680-A | FLUORESCENCE, ENZYMES, PROTEINS, DIGOXIGENIN, QUANTITATIVE ANALYSIS | BECKMAN INSTRUMENTS, INC. (US) | 1996-11-05 | — | — | US | disclosed |