Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA7 | P36544 | 3/20 | 0.60 |
| ▸ | CHRNA1 | P02708 | 2/20 | 0.60 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.60 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.60 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.60 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20881161 | 0.80 | CHRNA7 (0.60) | CHRNA7CHRNA1CHRNB2CHRNA3CHRNA4 | |
| Imidacloprid SCHEMBL22279 | 0.79 | CHRNA1 (0.59) | CHRNA7CHRNA1CHRNB2CHRNA3CHRNA4 | |
| Imidacloprid SCHEMBL29373384 | 0.79 | CHRNA1 (0.59) | CHRNA7CHRNA1CHRNB2CHRNA3CHRNA4 | |
| Imidacloprid SCHEMBL15690487 | 0.79 | CHRNA1 (0.59) | CHRNA7CHRNA1CHRNB2CHRNA3CHRNA4 | |
| Imidacloprid SCHEMBL28630962 | 0.78 | CHRNA1 (0.57) | CHRNA7CHRNA1CHRNB2CHRNA3CHRNA4 | |
| Imidacloprid SCHEMBL28312357 | 0.78 | CHRNA1 (0.57) | CHRNA7CHRNA1CHRNB2CHRNA3CHRNA4 | |
| Imidacloprid SCHEMBL28213953 | 0.78 | CHRNA1 (0.57) | CHRNA7CHRNA1CHRNB2CHRNA3CHRNA4 | |
| Imidacloprid SCHEMBL28262565 | 0.78 | CHRNA1 (0.57) | CHRNA7CHRNA1CHRNB2CHRNA3CHRNA4 | |
| Imidacloprid SCHEMBL28288562 | 0.77 | CHRNA1 (0.56) | CHRNA7CHRNA1CHRNB2CHRNA3CHRNA4 | |
| Desnitroimidacloprid SCHEMBL29823081 | 0.75 | CHRNB2 (1.00) | CHRNA7CHRNA1CHRNB2CHRNA3CHRNA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5547965-A | TREATMENT AND PREVENTION OF SENILE, PRESENILE, AND ALZHEIMER'S DEMENTIA, AND DEPRESSION | BAYER AKTIENGESELLSCHAFT (DE) | 1996-08-20 | — | — | US | claimed |
| EP-0679397-A2 | Use of substituted amines for the treatment of cerebral insufficiencies | BAYER AG (DE) | 1995-11-02 | — | — | EP | claimed |
| US-5547965-A | TREATMENT AND PREVENTION OF SENILE, PRESENILE, AND ALZHEIMER'S DEMENTIA, AND DEPRESSION | BAYER AKTIENGESELLSCHAFT (DE) | 1996-08-20 | — | — | US | disclosed |
| EP-0679397-A2 | Use of substituted amines for the treatment of cerebral insufficiencies | BAYER AG (DE) | 1995-11-02 | — | — | EP | disclosed |