SCHEMBL901461

SCHEMBL901461

CC(C)(C)OC(=O)NCCCC[C@H](NC(=O)OC(C)(C)C)C(=O)OCc1ccc(F)cc1-c1ccc2nc(N)nc(C(=O)N3Cc4ccccc4C3)c2c1

nearest known ligand 0.47

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
HSP90AA1 P07900 7/20 0.47
TDP1 Q9NUW8 1/20 0.44
HSP90AB1 P08238 2/20 0.42
CXCR3 P49682 3/20 0.38
KLK7 P49862 1/20 0.38
KLK5 Q9Y337 1/20 0.38
ITGB3 P05106 1/20 0.37
ITGA2B P08514 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15099531 0.97 HSP90AA1 (0.47) HSP90AA1TDP1HSP90AB1CXCR3KLK7
SCHEMBL902209 0.93 HSP90AA1 (0.54) HSP90AA1TDP1HSP90AB1CXCR3KLK7
SCHEMBL901739 0.93 HSP90AA1 (0.56) HSP90AA1TDP1HSP90AB1CXCR3KLK7
SCHEMBL17416333 0.91 HSP90AA1 (0.54) HSP90AA1TDP1HSP90AB1KLK7KLK5
SCHEMBL902136 0.89 HSP90AA1 (0.50) HSP90AA1HSP90AB1
SCHEMBL904245 0.86 HSP90AA1 (0.54) HSP90AA1HSP90AB1
SCHEMBL901501 0.85 HSP90AA1 (0.53) HSP90AA1TDP1HSP90AB1CXCR3
SCHEMBL902223 0.83 HSP90AA1 (0.53) HSP90AA1HSP90AB1
SCHEMBL901819 0.82 HSP90AA1 (0.57) HSP90AA1TDP1HSP90AB1
SCHEMBL902122 0.82 HSP90AA1 (0.55) HSP90AA1TDP1HSP90AB1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2621919-A1 PHENYLQUINAZOLINE DERIVATIVES Merck Patent GmbH (DE) 2013-08-07 EP claimed
WO-2012041435-A1 PHENYLQUINAZOLINE DERIVATIVES MERCK PATENT GMBH (DE) 2012-04-05 WO claimed
US-8791129-B2 Phenylquinazoline derivatives MERCK PATENT GMBH (DE) 2014-07-29 US disclosed
EP-2621919-A1 PHENYLQUINAZOLINE DERIVATIVES Merck Patent GmbH (DE) 2013-08-07 EP disclosed
WO-2012041435-A1 PHENYLQUINAZOLINE DERIVATIVES MERCK PATENT GMBH (DE) 2012-04-05 WO disclosed
WO-2012041435-A1 PHENYLQUINAZOLINE DERIVATIVES MERCK PATENT GMBH (DE) 2012-04-05 WO disclosed