SCHEMBL901501

SCHEMBL901501

CN(C)CCCC[C@H](NC(=O)OC(C)(C)C)C(=O)OCc1cc(F)c(F)cc1-c1ccc2nc(N)nc(C(=O)N3Cc4ccccc4C3)c2c1

nearest known ligand 0.53

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
HSP90AA1 P07900 11/20 0.53
HSP90AB1 P08238 3/20 0.42
TDP1 Q9NUW8 1/20 0.36
HDAC4 P56524 2/20 0.32
HDAC1 Q13547 2/20 0.32
CXCR3 P49682 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15099538 0.93 HSP90AA1 (0.57) HSP90AA1HSP90AB1
SCHEMBL902209 0.92 HSP90AA1 (0.54) HSP90AA1HSP90AB1TDP1CXCR3
SCHEMBL17416333 0.91 HSP90AA1 (0.54) HSP90AA1HSP90AB1TDP1
SCHEMBL901819 0.89 HSP90AA1 (0.57) HSP90AA1HSP90AB1TDP1
SCHEMBL902021 0.87 HSP90AA1 (0.58) HSP90AA1HSP90AB1
SCHEMBL901997 0.87 HSP90AA1 (0.58) HSP90AA1HSP90AB1TDP1
Hydrochloric Acid SCHEMBL901489 0.87 HSP90AA1 (0.57) HSP90AA1HSP90AB1
SCHEMBL901461 0.85 HSP90AA1 (0.47) HSP90AA1HSP90AB1TDP1CXCR3
SCHEMBL15099531 0.85 HSP90AA1 (0.47) HSP90AA1HSP90AB1TDP1CXCR3
SCHEMBL901739 0.84 HSP90AA1 (0.56) HSP90AA1HSP90AB1TDP1CXCR3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2621919-B1 PHENYLQUINAZOLINE DERIVATIVES MERCK PATENT GMBH (DE) 2016-01-13 EP claimed
EP-2621919-B1 PHENYLQUINAZOLINE DERIVATIVES MERCK PATENT GMBH (DE) 2016-01-13 EP disclosed
EP-2621919-B1 PHENYLQUINAZOLINE DERIVATIVES MERCK PATENT GMBH (DE) 2016-01-13 EP disclosed
US-8791129-B2 Phenylquinazoline derivatives MERCK PATENT GMBH (DE) 2014-07-29 US disclosed
EP-2621919-A1 PHENYLQUINAZOLINE DERIVATIVES Merck Patent GmbH (DE) 2013-08-07 EP disclosed
WO-2012041435-A1 PHENYLQUINAZOLINE DERIVATIVES MERCK PATENT GMBH (DE) 2012-04-05 WO disclosed
WO-2012041435-A1 PHENYLQUINAZOLINE DERIVATIVES MERCK PATENT GMBH (DE) 2012-04-05 WO disclosed