Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.40 |
| ▸ | BLM | P54132 | 1/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | GRIK1 | P39086 | 5/20 | 0.37 |
| ▸ | GRIK2 | Q13002 | 5/20 | 0.37 |
| ▸ | GRM1 | Q13255 | 2/20 | 0.37 |
| ▸ | GRM2 | Q14416 | 2/20 | 0.37 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.36 |
| ▸ | GABRR1 | P24046 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | GRM8 | O00222 | 1/20 | 0.34 |
| ▸ | GRM6 | O15303 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27581149 | 1.00 | TSHR (0.40) | TSHRSLC6A2SLC6A4BLMSLC6A3 | |
| SCHEMBL10657927 | 0.81 | TSHR (0.39) | TSHRSLC6A2SLC6A4BLMSLC6A3 | |
| SCHEMBL13074161 | 0.79 | GRM8 (0.60) | TSHRSLC6A2SLC6A4BLMSLC6A3 | |
| SCHEMBL6859985 | 0.79 | GRM8 (0.60) | TSHRSLC6A2SLC6A4BLMSLC6A3 | |
| Aspartic Acid SCHEMBL28676864 | 0.79 | GRIK1 (0.50) | GRIK1GRIK2GRM1GRM2LMNA | |
| SCHEMBL13282710 | 0.78 | SLC22A6 (0.38) | GRIK1GRIK2GRM1GRM2SLC22A6 | |
| SCHEMBL27562512 | 0.78 | TDP1 (0.42) | GRIK1GRIK2GRM1GRM2SLC22A6 | |
| SCHEMBL456956 | 0.78 | SLC22A6 (0.38) | GRIK1GRIK2GRM1GRM2SLC22A6 | |
| SCHEMBL4161262 | 0.78 | SLC22A6 (0.38) | GRIK1GRIK2GRM1GRM2SLC22A6 | |
| D-Aspartate SCHEMBL30284873 | 0.77 | GRIK1 (0.48) | TSHRBLMKMT2AGRIK1GRIK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0603268-B1 | WETTABLE SILICONE HYDROGEL COMPOSITIONS AND METHODS | BAUSCH & LOMB (US) | 1996-12-18 | — | — | EP | claimed |
| US-5451617-A | Wettable silicone hydrogel compositions and methods for their manufacture | BAUSCH & LOMB INCORPORATED (US) | 1995-09-19 | — | — | US | claimed |
| EP-0603268-B1 | WETTABLE SILICONE HYDROGEL COMPOSITIONS AND METHODS | BAUSCH & LOMB (US) | 1996-12-18 | — | — | EP | disclosed |
| US-5451617-A | Wettable silicone hydrogel compositions and methods for their manufacture | BAUSCH & LOMB INCORPORATED (US) | 1995-09-19 | — | — | US | disclosed |