Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB3 | P13945 | 15/20 | 0.59 |
| ▸ | ADRB2 | P07550 | 8/20 | 0.59 |
| ▸ | ADRB1 | P08588 | 8/20 | 0.59 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | HTR1A | P08908 | 1/20 | 0.47 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.47 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.47 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.47 |
| ▸ | HTR2B | P41595 | 1/20 | 0.47 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9015332 | 0.95 | ADRB3 (0.54) | ADRB3ADRB2ADRB1CYP2D6KMT2A | |
| SCHEMBL9015365 | 0.95 | ADRB3 (0.57) | ADRB3ADRB2ADRB1KMT2A | |
| SCHEMBL9015351 | 0.95 | ADRB3 (0.57) | ADRB3ADRB2ADRB1KMT2A | |
| SCHEMBL9015389 | 0.94 | ADRB3 (0.54) | ADRB3ADRB2ADRB1CYP2D6KMT2A | |
| SCHEMBL9015384 | 0.94 | ADRB3 (0.54) | ADRB3ADRB2ADRB1CYP2D6KMT2A | |
| SCHEMBL9015395 | 0.92 | ADRB3 (0.56) | ADRB3ADRB2ADRB1HTR1AADRA2C | |
| SCHEMBL9015347 | 0.92 | ADRB3 (0.58) | ADRB3ADRB2ADRB1HTR1AADRA2C | |
| SCHEMBL9015408 | 0.90 | ADRB3 (0.54) | ADRB3ADRB2ADRB1KMT2AHTR1A | |
| SCHEMBL9027131 | 0.89 | ADRB3 (0.60) | ADRB3ADRB2ADRB1 | |
| SCHEMBL9015345 | 0.89 | ADRB3 (0.60) | ADRB3ADRB2ADRB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0714883-A1 | Aryloxypropanolamine beta 3 adrenergic agonists | BRISTOL-MYERS SQUIBB COMPANY (US) | 1996-06-05 | — | — | EP | claimed |
| US-5541204-A | Aryloxypropanolamine β 3 adrenergic agonists | BRISTOL-MYERS SQUIBB COMPANY (US) | 1996-07-30 | — | — | US | disclosed |
| EP-0714883-A1 | Aryloxypropanolamine beta 3 adrenergic agonists | BRISTOL-MYERS SQUIBB COMPANY (US) | 1996-06-05 | — | — | EP | disclosed |