Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 1/20 | 0.73 |
| ▸ | CA1 | P00915 | 1/20 | 0.73 |
| ▸ | CA2 | P00918 | 1/20 | 0.73 |
| ▸ | CA9 | Q16790 | 1/20 | 0.73 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.70 |
| ▸ | MAPT | P10636 | 1/20 | 0.69 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.68 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.68 |
| ▸ | NAMPT | P43490 | 2/20 | 0.65 |
| ▸ | THRB | P10828 | 1/20 | 0.65 |
| ▸ | LMNA | P02545 | 1/20 | 0.65 |
| ▸ | MEN1 | O00255 | 2/20 | 0.64 |
| ▸ | GAA | P10253 | 1/20 | 0.64 |
| ▸ | PLAAT3 | P53816 | 1/20 | 0.64 |
| ▸ | PLAAT5 | Q96KN8 | 1/20 | 0.64 |
| ▸ | PLAAT2 | Q9NWW9 | 1/20 | 0.64 |
| ▸ | PLAAT4 | Q9UL19 | 1/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15476759 | 0.89 | CA12 (0.59) | CA12CA1CA2CA9ALDH1A1 | |
| SCHEMBL6418730 | 0.88 | MTNR1A (0.66) | CA12CA1CA2CA9ALDH1A1 | |
| SCHEMBL27160492 | 0.88 | GAA (0.60) | CA12CA1CA2CA9ALDH1A1 | |
| SCHEMBL2224069 | 0.87 | CA12 (0.73) | CA12CA1CA2CA9ALDH1A1 | |
| SCHEMBL8099685 | 0.87 | CA1 (0.73) | CA12CA1CA2CA9ALDH1A1 | |
| SCHEMBL10359474 | 0.87 | CA12 (0.73) | CA12CA1CA2CA9ALDH1A1 | |
| SCHEMBL7265002 | 0.87 | CA12 (0.73) | CA12CA1CA2CA9ALDH1A1 | |
| SCHEMBL17821665 | 0.86 | MTNR1A (0.65) | ALDH1A1MAPTKMT2ASMN1; SMN2LMNA | |
| SCHEMBL15319511 | 0.86 | CA12 (0.56) | CA12CA1CA2CA9ALDH1A1 | |
| Water SCHEMBL11279885 | 0.86 | CA12 (0.71) | CA12CA1CA2CA9ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1673337-A2 | ARYLALKYLCARBAMATE DERIVATIVES, PREPARATION METHOD THEREOF AND USE OF SAME IN THERAPEUTICS | Sanofi-Aventis (FR) | 2006-06-28 | — | — | EP | claimed |
| WO-2005033066-A2 | ARYLALKYLCARBAMATE DERIVATIVES, PREPARATION METHOD THEREOF AND USE OF SAME IN THERAPEUTICS | SANOFI-AVENTIS (FR) | 2005-04-14 | — | — | WO | claimed |
| EP-3099299-A1 | BENZOQUINOLINE INHIBITORS OF VESICULAR MONOAMINE TRANSPORTER 2 | Auspex Pharmaceuticals, Inc. (US) | 2016-12-07 | — | — | EP | disclosed |
| WO-2015112707-A1 | BENZOQUINOLINE INHIBITORS OF VESICULAR MONOAMINE TRANSPORTER 2 | AUSPEX PHARMACEUTICALS, INC. (US) | 2015-07-30 | — | — | WO | disclosed |
| CN-103232360-B | Process for the synthesis of ivabradine and addition salts thereof with a pharmaceutically acceptable acid | SERVIER LAB | 2014-05-21 | — | — | CN | disclosed |
| CN-102161642-B | Method for synthesizing ivabradine and pharmaceutically acceptable acid addition salts thereof | SERVIER LAB | 2014-03-19 | — | — | CN | disclosed |
| CN-103265491-A | New method for synthesising ivabradine and its addition salts | SERVIER LAB | 2013-08-28 | — | — | CN | disclosed |
| CN-103232360-A | Process for the synthesis of ivabradine and addition salts thereof with a pharmaceutically acceptable acid | SERVIER LAB | 2013-08-07 | — | — | CN | disclosed |
| EP-2576552-A2 | BENZOQUINOLONE INHIBITORS OF VMAT2 | Aupex Pharmaceutical, Inc. (US) | 2013-04-10 | — | — | EP | disclosed |
| EP-2364972-B1 | New method for synthesising ivabradine and its addition salts | SERVIER LAB (FR) | 2012-09-19 | — | — | EP | disclosed |
| WO-2012041934-A1 | POLYSUBSTITUTED 2-AMINOIMIDAZOLES FOR CONTROLLING BIOFILMS AND PROCESS FOR THEIR PRODUCTION | KATHOLIEKE UNIVERSITEIT LEUVEN (BE) | 2012-04-05 | — | — | WO | disclosed |
| WO-2011153157-A2 | BENZOQUINOLONE INHIBITORS OF VMAT2 | AUSPEX PHARMACEUTICAL, INC. (US) | 2011-12-08 | — | — | WO | disclosed |
| EP-2364972-A1 | New method for synthesising ivabradine and its addition salts | Les Laboratoires Servier (FR) | 2011-09-14 | — | — | EP | disclosed |
| WO-2011101558-A1 | NOVEL METHOD FOR SYNTHESIZING IVABRADINE AND THE PHARMACEUTICALLY ACCEPTABLE ACID ADDITION SALTS THEREOF | LES LABORATOIRES SERVIER (FR) | 2011-08-25 | — | — | WO | disclosed |
| EP-1972616-A1 | Derivatives of arylalkylcarbamates, process for their preparation and therapeutic application thereof | Sanofi-Aventis (FR) | 2008-09-24 | — | — | EP | disclosed |
| EP-1673337-A2 | ARYLALKYLCARBAMATE DERIVATIVES, PREPARATION METHOD THEREOF AND USE OF SAME IN THERAPEUTICS | Sanofi-Aventis (FR) | 2006-06-28 | — | — | EP | disclosed |
| WO-2005033066-A2 | ARYLALKYLCARBAMATE DERIVATIVES, PREPARATION METHOD THEREOF AND USE OF SAME IN THERAPEUTICS | SANOFI-AVENTIS (FR) | 2005-04-14 | — | — | WO | disclosed |
| US-4009170-A | 1-Ethoxy-3,4-dihydroisoquindines | STERLING DRUG INC. (US) | 1977-02-22 | — | — | US | disclosed |