Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.54 |
| ▸ | SRC | P12931 | 2/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.50 |
| ▸ | CES2 | O00748 | 2/20 | 0.48 |
| ▸ | CES1 | P23141 | 2/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.43 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.43 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.43 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.43 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.43 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.43 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4348933 | 0.92 | LMNA (0.48) | LMNAMAPK1SRCCYP2D6L3MBTL1 | |
| Anthracene SCHEMBL28466109 | 0.80 | UGT2B7 (0.43) | LMNAMAPK1CYP2D6 | |
| Diphenylmethanol SCHEMBL9188301 | 0.78 | LMNA (0.59) | LMNAMAPK1SRCCYP2D6CES2 | |
| SCHEMBL8109262 | 0.77 | LMNA (0.58) | LMNAMAPK1SRCCYP2D6CES2 | |
| SCHEMBL28735249 | 0.77 | LMNA (0.52) | LMNAMAPK1SRCCYP2D6CES2 | |
| SCHEMBL8579904 | 0.76 | LMNA (0.44) | LMNAMAPK1SRCCYP2D6CES2 | |
| SCHEMBL1742565 | 0.76 | SRC (0.59) | LMNAMAPK1SRCCYP2D6CES2 | |
| Bicarbonate SCHEMBL7286375 | 0.75 | HDAC1 (0.58) | LMNAMAPK1SRCCYP2D6CES2 | |
| SCHEMBL6573477 | 0.74 | LMNA (0.42) | LMNAMAPK1L3MBTL1 | |
| Phenyl Ethanol SCHEMBL28552574 | 0.74 | LMNA (0.54) | LMNAMAPK1SRCCYP2D6CES2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 27 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5585177-A | FLAVOR RETENTION; FOOD AND BEVERAGE PACKAGING | TOYO KOHAN CO., LTD. (JP) | 1996-12-17 | — | — | US | disclosed |
| EP-0209393-B1 | DEEP-DRAW-FORMED VESSEL AND PROCESS FOR PREPARATION THEREOF | TOYO SEIKAN KAISHA LIMITED (JP) | 1991-05-02 | — | — | EP | disclosed |
| US-4858782-A | Metal vessel having circumferential side seam and process for production thereof | TOYO SEIKAN KAISHA, LTD. (JP) | 1989-08-22 | — | — | US | disclosed |
| EP-0182646-B1 | PACKAGING MATERIAL COMPRISING IRON FOIL, AND CONTAINER AND CONTAINER LID COMPOSED THEREOF | TOYO SEIKAN KAISHA LIMITED (JP) | 1989-03-15 | — | — | EP | disclosed |
| US-4734303-A | METAL FOIL, PLASTIC FILM | TOYO SEIKAN KAISHA, LTD. (JP) | 1988-03-29 | — | — | US | disclosed |
| US-4686152-A | THERMOPLASTIC RESIN LAMINATE | TOYO SEIKAN KAISHA, LTD. (JP) | 1987-08-11 | — | — | US | disclosed |
| EP-0209393-A2 | Deep-draw-formed vessel and process for preparation thereof | TOYO SEIKAN KAISHA LIMITED (JP) | 1987-01-21 | — | — | EP | disclosed |
| EP-0182646-A2 | Packaging material comprising iron foil, and container and container lid composed thereof | TOYO SEIKAN KAISHA LIMITED (JP) | 1986-05-28 | — | — | EP | disclosed |
| EP-0078625-B1 | EASILY-OPENABLE HEAT SEAL LID | TOYO SEIKAN KAISHA LIMITED (JP) | 1986-03-05 | — | — | EP | disclosed |
| EP-0079136-B1 | PROCESS FOR PREPARATION OF METAL VESSELS | TOYO SEIKAN KAISHA LIMITED (JP) | 1986-01-29 | — | — | EP | disclosed |
| US-4428494-A | Easily-openable heat seal lid | TOYO SEIKAN KAISHA, LTD. (JP) | 1984-01-31 | — | — | US | disclosed |
| US-4403710-A | Easily-openable heat seal lid | TOYO SEIKAN KAISHA LTD. (JP) | 1983-09-13 | — | — | US | disclosed |
| EP-0079136-A1 | Process for preparation of metal vessels | TOYO SEIKAN KAISHA LIMITED (JP) | 1983-05-18 | — | — | EP | disclosed |
| EP-0078625-A1 | Easily-openable heat seal lid | TOYO SEIKAN KAISHA LIMITED (JP) | 1983-05-11 | — | — | EP | disclosed |
| US-4382525-A | THERMOSETTING AND THERMOPLASTIC RESINS | TOYO SEIKAN KAISHA, LTD. (JP) | 1983-05-10 | — | — | US | disclosed |
| EP-0076634-A1 | Process for preparation of metallic bottles | TOYO SEIKAN KAISHA LIMITED (JP) | 1983-04-13 | — | — | EP | disclosed |
| EP-0075427-A2 | Metal vessel having circumferential side seam and process for production thereof | TOYO SEIKAN KAISHA LIMITED (JP) | 1983-03-30 | — | — | EP | disclosed |
| EP-0065417-A2 | Easily-openable heat seal lid | TOYO SEIKAN KAISHA LIMITED (JP) | 1982-11-24 | — | — | EP | disclosed |
| US-3975463-A | Molded structures containing crystalling polyolefin saponified ethylene vinyl acetate copolymer and carbonyl containing copolymers | TOYO SEIKAN KAISHA LIMITED (JA) | 1976-08-17 | — | — | US | disclosed |
| US-3932692-A | Resinious laminates having improved gas permeation and delamination resistance | TOYO SEIKAN KAISHA LIMITED (JA) | 1976-01-13 | — | — | US | disclosed |