SCHEMBL901648

SCHEMBL901648

CC(=O)C(C)(Cl)C(=O)O

nearest known ligand 0.00

⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9705775 0.83
SCHEMBL2419386 0.75 ALDH1A1 (0.38)
SCHEMBL5944823 0.73
Acetic Acid SCHEMBL27352200 0.73 TSHR (0.50)
Dalapon SCHEMBL7218827 0.73 TSHR (0.50)
SCHEMBL9860804 0.73
SCHEMBL14655349 0.73
SCHEMBL301323 0.72
SCHEMBL538844 0.72
Dalapon SCHEMBL45164 0.72

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 47 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-10093663-B2 Piperidinyl-indole derivatives complement factor B inhibitors and uses thereof NOVARTIS AG (CH) 2018-10-09 US disclosed
EP-3299365-A1 PIPERIDINYL-INDOLE DERIVATIVES COMPLEMENT FACTOR B INHIBITORS AND USES THEREOF Novartis AG (CH) 2018-03-28 EP disclosed
US-20180009795-A1 Piperidinyl-Indole Derivatives Complement Factor B Inhibitors and Uses Thereof NOVARTIS AG (CH) 2018-01-11 US disclosed
EP-3022192-B1 PIPERIDINYL INDOLE DERIVATIVES AND THEIR USE AS COMPLEMENT FACTOR B INHIBITORS NOVARTIS AG (CH) 2017-10-11 EP disclosed
US-9682968-B2 Piperidinyl-indole derivatives complement factor B inhibitors and uses thereof NOVARTIS AG (CH) 2017-06-20 US disclosed
US-20160152605-A1 Piperidinyl-Indole Derivatives Complement Factor B Inhibitors and Uses Thereof NOVARTIS AG (CH) 2016-06-02 US disclosed
EP-3022192-A1 PIPERIDINYL INDOLE DERIVATIVES AND THEIR USE AS COMPLEMENT FACTOR B INHIBITORS Novartis AG (CH) 2016-05-25 EP disclosed
WO-2015009616-A1 PIPERIDINYL INDOLE DERIVATIVES AND THEIR USE AS COMPLEMENT FACTOR B INHIBITORS NOVARTIS AG (CH) 2015-01-22 WO disclosed
US-20130252951-A1 7-HYDROXY-PYRAZOLO[1,5-A] PYRIMIDINE COMPOUNDS AND THEIR USE AS CCR2 RECEPTOR ANTAGONISTS PROXIMAGEN LIMITED (GB) 2013-09-26 US disclosed
EP-2621928-A1 7-HYDROXY-PYRAZOLO[1,5-A]PYRIMIDINE COMPOUNDS AND THEIR USE AS CCR2 RECEPTOR ANTAGONISTS Proximagen Limited (GB) 2013-08-07 EP disclosed
EP-0330678-A1 INSECTICIDAL PYRAZOLINES. DU PONT (US) 1989-09-06 EP disclosed
EP-0183797-B1 5-HALO-4H-1,3-DIOXIN-4-ONE COMPOUNDS, PROCESS FOR THEIR PREPARATION AND THEIR USE IN THE PREPARATION OF ALPHA-HALO-ACETOACETIC ESTERS EASTMAN KODAK COMPANY (a New Jersey corporation) (US) 1989-07-19 EP disclosed
WO-1988006583-A1 INSECTICIDAL PYRAZOLINES E.I. DU PONT DE NEMOURS AND COMPANY (US) 1988-09-07 WO disclosed
EP-0212753-A1 Diphenyl ether Herbicides SHELL INTERNATIONALE RESEARCHMAATSCHAPPIJ B.V. (NL) 1987-03-04 EP disclosed
US-4633013-A Preparation of α-haloacetoacetic esters EASTMAN KODAK COMPANY (US) 1986-12-30 US disclosed
EP-0183797-A1 5-HALO-4H-1,3-DIOXIN-4-ONE COMPOUNDS, PROCESS FOR THEIR PREPARATION AND THEIR USE IN THE PREPARATION OF ALPHA-HALO-ACETOACETIC ESTERS. EASTMAN KODAK CO (US) 1986-06-11 EP disclosed
US-4582913-A 5-halo-4H-1,3-dioxin-4-one compounds EASTMAN KODAK COMPANY (US) 1986-04-15 US disclosed
WO-1986000068-A1 5-HALO-4H-1,3-DIOXIN-4-ONE COMPOUNDS, alpha-HALO-ACETOACETIC ESTERS PREPARED FROM SUCH COMPOUNDS AND PROCESS FOR THEIR PREPARATION EASTMAN KODAK COMPANY (DE) 1986-01-03 WO disclosed
US-3965168-A CITRIC ACID INTERMEDIATE ETHYL CORPORATION (US) 1976-06-22 US disclosed
US-3960941-A CHEMICAL INTERMEDIATE FOR CITRIC ACID ETHYL CORPORATION (US) 1976-06-01 US disclosed