SCHEMBL9016537

SCHEMBL9016537

COc1cc(C=O)c(Br)c(Cl)c1O

nearest known ligand 0.58

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
ERN1 O75460 16/20 0.58
PRKDC P78527 1/20 0.51
KDM4E B2RXH2 1/20 0.47
ALDH1A1 P00352 1/20 0.47
TSHR P16473 1/20 0.47
TDP1 Q9NUW8 1/20 0.47
TLR2 O60603 1/20 0.45
TLR1 Q15399 1/20 0.45
TLR6 Q9Y2C9 1/20 0.45
LMNA P02545 1/20 0.44
MAPT P10636 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL24140773 0.84 ERN1 (0.64) ERN1PRKDCKDM4EALDH1A1TSHR
SCHEMBL7966625 0.84 ERN1 (0.64) ERN1PRKDCKDM4EALDH1A1TSHR
SCHEMBL1646879 0.84 ERN1 (0.64) ERN1PRKDCKDM4EALDH1A1TSHR
SCHEMBL15534494 0.81 ERN1 (0.73) ERN1PRKDCKDM4EALDH1A1TSHR
SCHEMBL23094539 0.81 ERN1 (0.60) ERN1PRKDCKDM4EALDH1A1TSHR
SCHEMBL9861378 0.81 ERN1 (0.60) ERN1PRKDCKDM4EALDH1A1TSHR
SCHEMBL9016756 0.81 PRKDC (0.53) ERN1PRKDCKDM4EALDH1A1TSHR
SCHEMBL9860690 0.78 ERN1 (0.57) ERN1PRKDCKDM4EALDH1A1TSHR
SCHEMBL24984316 0.78 ERN1 (0.55) ERN1KDM4EALDH1A1TSHRTDP1
SCHEMBL17263377 0.76 ERN1 (0.54) ERN1KDM4EALDH1A1TSHRTDP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-10947206-B2 cGAS antagonist compounds IMMUNESENSOR THERAPEUTICS, INC. (US) 2021-03-16 US disclosed
EP-0481441-B1 Novel cephem compounds, their preparation processes and antibacterial agents KYORIN SEIYAKU KK (JP) 1996-12-11 EP disclosed
US-5244892-A Pseudomonas KYORIN PHARMACEUTICAL CO., LTD. (JP) 1993-09-14 US disclosed
EP-0481441-A2 Novel cephem compounds, their preparation processes and antibacterial agents KYORIN PHARMACEUTICAL CO., LTD. (JP) 1992-04-22 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10947206-B2 cGAS antagonist compounds CGAS, STING1, GLS2 ERN1 2251/4885PRKDC 1829/4885KDM4E 4717/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.