SCHEMBL9016958

SCHEMBL9016958

C/C=C/C1CCC(c2ccc(-c3ccc(-c4ccc(O)c(F)c4F)cc3)c(F)c2)CO1

nearest known ligand 0.33

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 3/20 0.33
CYP2C9 P11712 2/20 0.33
APP P05067 2/20 0.33
CYP2D6 P10635 1/20 0.32
CYP2C19 P33261 1/20 0.32
FASN P49327 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8944362 0.88 CYP3A4 (0.31) CYP3A4CYP2C9APPCYP2D6CYP2C19
SCHEMBL9016950 0.87 CYP3A4 (0.32) CYP3A4CYP2C9APPCYP2D6CYP2C19
SCHEMBL9016921 0.87 CYP3A4 (0.30) CYP3A4CYP2C9APP
SCHEMBL13263057 0.86 CYP3A4 (0.32) CYP3A4CYP2C9APPCYP2D6CYP2C19
SCHEMBL8944482 0.86 FPR2 (0.35) CYP3A4CYP2C9APP
SCHEMBL8944375 0.86 FASN (0.33) CYP3A4CYP2C9APPCYP2D6CYP2C19
SCHEMBL9017455 0.85 ALOX5AP (0.31)
SCHEMBL8944202 0.84 FPR2 (0.35) FASN
SCHEMBL8944462 0.84 FASN (0.31) FASN
SCHEMBL9013724 0.84 CYP3A4 (0.38) CYP3A4CYP2C9APPCYP2D6CYP2C19

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8187494-B2 Four- or five-ring liquid crystal compound having lateral fluorine, liquid crystal composition, and liquid crystal display device JNC CORPORATION (JP) 2012-05-29 US disclosed
EP-2206695-A1 TETRA- OR PENTA-CYCLIC LIQUID CRYSTALLINE COMPOUND HAVING LATERAL FLUORINE, LIQUID CRYSTAL COMPOSITION, AND LIQUID CRYSTAL DISPLAY ELEMENT Chisso Corporation (JP) 2010-07-14 EP disclosed