Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 8/20 | 0.61 |
| ▸ | NPC1 | O15118 | 2/20 | 0.60 |
| ▸ | RAB9A | P51151 | 2/20 | 0.60 |
| ▸ | POLB | P06746 | 1/20 | 0.60 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.60 |
| ▸ | ABCG2 | Q9UNQ0 | 6/20 | 0.60 |
| ▸ | HTT | P42858 | 3/20 | 0.60 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.60 |
| ▸ | LTK | P29376 | 2/20 | 0.60 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.60 |
| ▸ | LIMK1 | P53667 | 2/20 | 0.60 |
| ▸ | ACVR1 | Q04771 | 2/20 | 0.60 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.60 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.60 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.60 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.60 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.60 |
| ▸ | DYRK1B | Q9Y463 | 2/20 | 0.60 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.60 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31620745 | 0.83 | MEN1 (0.64) | EGFRNPC1RAB9APOLBMAPK1 | |
| SCHEMBL8976752 | 0.82 | EGFR (0.78) | EGFRNPC1RAB9APOLBMAPK1 | |
| SCHEMBL31620725 | 0.81 | NPC1 (0.57) | EGFRNPC1RAB9APOLBMAPK1 | |
| SCHEMBL15452546 | 0.77 | NPC1 (0.54) | EGFRNPC1RAB9APOLBMAPK1 | |
| SCHEMBL5566242 | 0.76 | HTT (0.72) | EGFRNPC1RAB9APOLBMAPK1 | |
| SCHEMBL3391554 | 0.76 | EGFR (1.00) | EGFRNPC1RAB9APOLBMAPK1 | |
| SCHEMBL5569191 | 0.76 | GAA (0.65) | EGFRNPC1RAB9APOLBMAPK1 | |
| Hydrochloric Acid SCHEMBL9017037 | 0.75 | HTT (0.81) | EGFRNPC1RAB9APOLBMAPK1 | |
| SCHEMBL8920 | 0.75 | EGFR (1.00) | EGFRNPC1RAB9APOLBMAPK1 | |
| SCHEMBL29941271 | 0.75 | EGFR (1.00) | EGFRNPC1RAB9APOLBMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0520722-B1 | Therapeutic preparations containing quinazoline derivatives | ZENECA LTD (GB) | 1996-12-27 | — | — | EP | disclosed |
| EP-0520722-A1 | Therapeutic preparations containing quinazoline derivatives | ZENECA LIMITED (GB) | 1992-12-30 | — | — | EP | disclosed |