Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 12/20 | 0.63 |
| ▸ | LCK | P06239 | 2/20 | 0.63 |
| ▸ | MAPT | P10636 | 1/20 | 0.62 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.62 |
| ▸ | NPC1 | O15118 | 1/20 | 0.61 |
| ▸ | HTT | P42858 | 1/20 | 0.61 |
| ▸ | RAB9A | P51151 | 1/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.61 |
| ▸ | GAK | O14976 | 1/20 | 0.61 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.58 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.58 |
| ▸ | ABCG2 | Q9UNQ0 | 2/20 | 0.58 |
| ▸ | KDR | P35968 | 3/20 | 0.56 |
| ▸ | CSF1R | P07333 | 1/20 | 0.56 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL11094065 | 0.99 | EGFR (0.64) | EGFRLCKMAPTGRM1NPC1 | |
| SCHEMBL5740105 | 0.88 | EGFR (0.69) | EGFRHTTRAB9AGAKABCG2 | |
| SCHEMBL11088081 | 0.83 | EGFR (0.69) | EGFRLCKHTTABCG2KDR | |
| Hydrochloric Acid SCHEMBL11085999 | 0.82 | TSHR (0.70) | EGFRLCKHTTABCG2KDR | |
| SCHEMBL5864703 | 0.81 | EGFR (0.84) | EGFRLCKGAKABCG2KDR | |
| Hydrochloric Acid SCHEMBL8808833 | 0.81 | EGFR (0.68) | EGFRMAPTNPC1HTTRAB9A | |
| SCHEMBL11083409 | 0.81 | EGFR (0.67) | EGFRLCKMAPTGRM1NPC1 | |
| SCHEMBL22137768 | 0.81 | TTBK1 (0.61) | EGFRGAKKDRCSF1RTRPV1 | |
| Hydrochloric Acid SCHEMBL11086239 | 0.80 | EGFR (0.68) | EGFRLCKMAPTGRM1NPC1 | |
| Hydrochloric Acid SCHEMBL10496016 | 0.78 | EGFR (0.54) | EGFRHTTGAKABCG2KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0520722-B1 | Therapeutic preparations containing quinazoline derivatives | ZENECA LTD (GB) | 1996-12-27 | — | — | EP | claimed |
| EP-0520722-B1 | Therapeutic preparations containing quinazoline derivatives | ZENECA LTD (GB) | 1996-12-27 | — | — | EP | disclosed |
| US-4464375-A | ANALGESIC, ANTIINFLAMMATORY | SANKYO CO., LTD. (JP) | 1984-08-07 | — | — | US | disclosed |
| US-4322420-A | Method of using 4-anilinoquinazoline derivatives as analgesic and anti-inflammatory agents | SANKYO COMPANY LIMITED (JP) | 1982-03-30 | — | — | US | disclosed |