Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 13/20 | 0.68 |
| ▸ | FADS1 | O60427 | 2/20 | 0.68 |
| ▸ | LCK | P06239 | 2/20 | 0.66 |
| ▸ | TTBK1 | Q5TCY1 | 1/20 | 0.60 |
| ▸ | TTBK2 | Q6IQ55 | 1/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.59 |
| ▸ | MAPT | P10636 | 3/20 | 0.59 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.59 |
| ▸ | MEN1 | O00255 | 2/20 | 0.59 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.59 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.59 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.59 |
| ▸ | NPC1 | O15118 | 1/20 | 0.59 |
| ▸ | PRNP | P04156 | 1/20 | 0.59 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.59 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.59 |
| ▸ | HTT | P42858 | 1/20 | 0.59 |
| ▸ | ABL1 | P00519 | 2/20 | 0.56 |
| ▸ | ABL2 | P42684 | 2/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL11091908 | 0.99 | EGFR (0.68) | EGFRFADS1LCKTTBK1TTBK2 | |
| SCHEMBL11092859 | 0.86 | EGFR (0.58) | EGFRFADS1LCKTTBK1TTBK2 | |
| SCHEMBL4787336 | 0.86 | EGFR (0.64) | EGFRFADS1LCKTTBK1TTBK2 | |
| SCHEMBL5568231 | 0.86 | EGFR (0.64) | EGFRFADS1LCKTTBK1TTBK2 | |
| Hydrochloric Acid SCHEMBL11089262 | 0.85 | EGFR (0.57) | EGFRFADS1LCKTTBK1TTBK2 | |
| SCHEMBL29352479 | 0.81 | EGFR (1.00) | EGFRFADS1LCKKDM4EMAPT | |
| SCHEMBL136003 | 0.81 | EGFR (1.00) | EGFRFADS1LCKKDM4EMAPT | |
| Hydrochloric Acid SCHEMBL9017042 | 0.79 | EGFR (1.00) | EGFRFADS1LCKKDM4EMAPT | |
| SCHEMBL809840 | 0.78 | EGFR (0.71) | EGFRFADS1LCKTTBK1TTBK2 | |
| SCHEMBL4740535 | 0.78 | EGFR (0.58) | EGFRFADS1LCKTTBK1TTBK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0520722-B1 | Therapeutic preparations containing quinazoline derivatives | ZENECA LTD (GB) | 1996-12-27 | — | — | EP | claimed |
| EP-0520722-A1 | Therapeutic preparations containing quinazoline derivatives | ZENECA LIMITED (GB) | 1992-12-30 | — | — | EP | claimed |
| EP-0520722-B1 | Therapeutic preparations containing quinazoline derivatives | ZENECA LTD (GB) | 1996-12-27 | — | — | EP | disclosed |
| EP-0520722-A1 | Therapeutic preparations containing quinazoline derivatives | ZENECA LIMITED (GB) | 1992-12-30 | — | — | EP | disclosed |
| US-4464375-A | ANALGESIC, ANTIINFLAMMATORY | SANKYO CO., LTD. (JP) | 1984-08-07 | — | — | US | disclosed |
| US-4322420-A | Method of using 4-anilinoquinazoline derivatives as analgesic and anti-inflammatory agents | SANKYO COMPANY LIMITED (JP) | 1982-03-30 | — | — | US | disclosed |