Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 8/20 | 0.70 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.68 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.68 |
| ▸ | HTT | P42858 | 1/20 | 0.68 |
| ▸ | ABCG2 | Q9UNQ0 | 2/20 | 0.67 |
| ▸ | CLK4 | Q9HAZ1 | 3/20 | 0.66 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.66 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.66 |
| ▸ | ABL1 | P00519 | 1/20 | 0.66 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.66 |
| ▸ | PIM1 | P11309 | 1/20 | 0.66 |
| ▸ | PRKACA | P17612 | 1/20 | 0.66 |
| ▸ | LTK | P29376 | 1/20 | 0.66 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.66 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.66 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.66 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.66 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.66 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.66 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.66 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27878333 | 0.90 | USP2 (0.65) | EGFRABCG2CLK4RAF1BRAF | |
| SCHEMBL8933760 | 0.89 | KDR (0.73) | EGFRMAPK1KDM4EHTTCLK4 | |
| Hydrochloric Acid SCHEMBL8808497 | 0.88 | KDR (0.71) | EGFRHTTERBB2KDR | |
| SCHEMBL5569052 | 0.88 | EGFR (0.70) | EGFRMAPK1KDM4EHTTABCG2 | |
| Hydrochloric Acid SCHEMBL11087812 | 0.86 | EGFR (0.68) | EGFRMAPK1KDM4EHTTABCG2 | |
| SCHEMBL4738649 | 0.84 | EGFR (0.80) | EGFRKDM4EHTTABCG2ERBB2 | |
| SCHEMBL8427296 | 0.84 | EGFR (0.74) | EGFRMAPK1KDM4EHTTABCG2 | |
| Hydrochloric Acid SCHEMBL8427224 | 0.83 | EGFR (0.72) | EGFRMAPK1KDM4EHTTABCG2 | |
| Hydrochloric Acid SCHEMBL8812620 | 0.83 | EGFR (0.76) | EGFRCLK4ERBB2AURKBKDR | |
| SCHEMBL8225745 | 0.83 | KDM4E (0.73) | EGFRMAPK1KDM4EHTTABCG2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0520722-B1 | Therapeutic preparations containing quinazoline derivatives | ZENECA LTD (GB) | 1996-12-27 | — | — | EP | disclosed |
| EP-0520722-A1 | Therapeutic preparations containing quinazoline derivatives | ZENECA LIMITED (GB) | 1992-12-30 | — | — | EP | disclosed |