Adipic Acid

Adipic Acid

SCHEMBL9017423

O=C(O)CCCCC(=O)O.O=C(O)c1ccc(-c2ccc(C(=O)O)cc2)cc1.O=C1OCCOC(=O)c2ccc1cc2

nearest known ligand 0.47

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

SLC18A2SLC6A2SLC6A3

The experimentally established mechanism targets of Adipic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SMN1; SMN2 Q16637 2/20 0.44
FFAR1 O14842 1/20 0.44
LMNA P02545 1/20 0.44
CYP1A2 P05177 1/20 0.44
RAB9A P51151 1/20 0.44
HIF1A Q16665 1/20 0.44
SRD5A2 P31213 1/20 0.41
HDAC3 O15379 1/20 0.41
HDAC4 P56524 1/20 0.41
HDAC1 Q13547 1/20 0.41
HDAC7 Q8WUI4 1/20 0.41
HDAC2 Q92769 1/20 0.41
HDAC10 Q969S8 1/20 0.41
HDAC11 Q96DB2 1/20 0.41
HDAC8 Q9BY41 1/20 0.41
HDAC6 Q9UBN7 1/20 0.41
HDAC9 Q9UKV0 1/20 0.41
HDAC5 Q9UQL6 1/20 0.41
PKM P14618 1/20 0.41
TSHR P16473 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Terephthalic Acid SCHEMBL9267638 0.98 HDAC3 (0.42) SMN1; SMN2FFAR1LMNACYP1A2RAB9A
Terephthalic Acid SCHEMBL28482093 0.92 SMN1; SMN2 (0.42) SMN1; SMN2FFAR1LMNACYP1A2RAB9A
Adipic Acid SCHEMBL1325137 0.90 HDAC3 (0.44) SMN1; SMN2FFAR1LMNACYP1A2RAB9A
Sebacic Acid SCHEMBL1326001 0.89 HDAC3 (0.47) SMN1; SMN2LMNARAB9AHDAC3HDAC4
Azelaic Acid SCHEMBL7057781 0.89 HDAC3 (0.47) SMN1; SMN2LMNARAB9AHDAC3HDAC4
SCHEMBL11859636 0.89 HDAC3 (0.47) SMN1; SMN2LMNARAB9AHDAC3HDAC4
SCHEMBL5319785 0.88 BCL2L1 (0.50) RAB9ASRD5A2TSHRBCL2L1BAD
Isophthalic Acid SCHEMBL1325825 0.88 HDAC3 (0.42) SMN1; SMN2LMNAHDAC3HDAC4HDAC1
Glutarate SCHEMBL11316852 0.87 SMN1; SMN2 (0.42) SMN1; SMN2FFAR1LMNACYP1A2RAB9A
Azelaic Acid SCHEMBL10396106 0.87 HDAC3 (0.45) SMN1; SMN2LMNARAB9AHDAC3HDAC4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0674587-A4 IMPROVED BIAXIALLY ORIENTED COPOLYESTER FILM FOR MAGNETIC RECORDING MEDIA. HOECHST AG (DE) 1996-02-28 EP disclosed
EP-0675803-A1 BIAXIALLY ORIENTED COPOLYESTER/POLYOLEFIN BI- OR TRILAYER FILM AND METHOD FOR MAKING THE SAME HOECHST AKTIENGESELLSCHAFT (DE) 1995-10-11 EP disclosed
EP-0674587-A1 IMPROVED BIAXIALLY ORIENTED COPOLYESTER FILM FOR MAGNETIC RECORDING MEDIA HOECHST AKTIENGESELLSCHAFT (DE) 1995-10-04 EP disclosed
EP-0671990-A1 BIAXIALLY ORIENTED COPOLYESTER FILM FOR CAPACITOR DIELECTRIC USE OR THERMAL TRANSFER RIBBON USE HOECHST AKTIENGESELLSCHAFT (DE) 1995-09-20 EP disclosed
EP-0675803-A4 BIAXIALLY ORIENTED COPOLYESTER/POLYOLEFIN BI- OR TRILAYER FILM AND METHOD FOR MAKING THE SAME. HOECHST AG (DE) 1995-08-10 EP disclosed
EP-0671990-A4 BIAXIALLY ORIENTED COPOLYESTER FILM FOR CAPACITOR DIELECTRIC USE OR THERMAL TRANSFER RIBBON USE. HOECHST AG (DE) 1995-08-01 EP disclosed
WO-1994013475-A1 BIAXIALLY ORIENTED COPOLYESTER/POLYOLEFIN BI- OR TRILAYER FILM AND METHOD FOR MAKING THE SAME HOECHST AKTIENGESELLSCHAFT (DE) 1994-06-23 WO disclosed
WO-1994013483-A1 IMPROVED BIAXIALLY ORIENTED COPOLYESTER FILM FOR MAGNETIC RECORDING MEDIA HOECHST AKTIENGESELLSCHAFT (DE) 1994-06-23 WO disclosed
WO-1994013464-A1 BIAXIALLY ORIENTED COPOLYESTER FILM FOR CAPACITOR DIELECTRIC USE OR THERMAL TRANSFER RIBBON USE HOECHST AKTIENGESELLSCHAFT (DE) 1994-06-23 WO disclosed