Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.43 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.43 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.43 |
| ▸ | MMP8 | P22894 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2325747 | 0.87 | KMT2A (0.47) | LMNAL3MBTL1NPC1SMN1; SMN2RAB9A | |
| SCHEMBL7587366 | 0.87 | KMT2A (0.47) | LMNAL3MBTL1NPC1SMN1; SMN2RAB9A | |
| SCHEMBL2081536 | 0.87 | KMT2A (0.47) | LMNAL3MBTL1NPC1SMN1; SMN2RAB9A | |
| SCHEMBL10808641 | 0.85 | TSHR (0.46) | LMNAL3MBTL1NPC1SMN1; SMN2RAB9A | |
| SCHEMBL15526544 | 0.84 | KMT2A (0.45) | LMNAATMPIN1NPC1SMN1; SMN2 | |
| SCHEMBL14258470 | 0.84 | LMNA (0.43) | LMNAL3MBTL1NPC1SMN1; SMN2RAB9A | |
| SCHEMBL10012543 | 0.83 | KMT2A (0.48) | LMNAL3MBTL1ATMSMN1; SMN2ALDH1A1 | |
| SCHEMBL10012053 | 0.83 | MEN1 (0.36) | LMNAATMNPC1SMN1; SMN2RAB9A | |
| SCHEMBL10011972 | 0.82 | CYP3A4 (0.44) | LMNAATMSMN1; SMN2RAB9AALDH1A1 | |
| SCHEMBL10011594 | 0.82 | NPC1 (0.44) | LMNAATMNPC1SMN1; SMN2RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-8231468-A | — | — | None | — | — | JP | disclosed |
| JP-H08231468-A | LIQUID CRYSTAL COMPOUND | UK GOVERNMENT | 1996-09-10 | — | — | JP | disclosed |
| CN-1017242-B | NEW QUIANZOLINE DERIVATIVES AND PROCESS FOR THEIR PRODUCTION | FUJISAWA PHARMACEUTICAL CO (JP) | 1992-07-01 | — | — | CN | disclosed |
| US-4883800-A | DIABETES | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1989-11-28 | — | — | US | disclosed |
| US-4734419-A | Quinazoline derivatives, compositions thereof and their use in treating diabetic complications | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1988-03-29 | — | — | US | disclosed |
| CN-86106984-A | New quinazoline derivant and preparation method thereof | — | 1987-05-20 | — | — | CN | disclosed |
| EP-0218999-A2 | New quinazoline derivatives, process for their production and pharmaceutical compositions comprising them | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1987-04-22 | — | — | EP | disclosed |