Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 9/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | CA1 | P00915 | 4/20 | 0.41 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.35 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.35 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | Q9HBH1 | 1/20 | 0.33 | |
| ▸ | CTSK | P43235 | 2/20 | 0.32 |
| ▸ | CTSS | P25774 | 1/20 | 0.32 |
| ▸ | GPR84 | Q9NQS5 | 3/20 | 0.32 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28647023 | 0.83 | CA2 (0.44) | CA2MAPK1CA1SLC1A3SLC1A2 | |
| SCHEMBL1404250 | 0.80 | CA2 (0.39) | CA2MAPK1CA1SLC1A3SLC1A2 | |
| SCHEMBL3281927 | 0.80 | CA2 (0.42) | CA2MAPK1CA1SLC1A3SLC1A2 | |
| SCHEMBL14690763 | 0.78 | CA2 (0.40) | CA2MAPK1CA1SLC1A3SLC1A2 | |
| SCHEMBL1404251 | 0.78 | CA2 (0.40) | CA2MAPK1CA1SLC1A3SLC1A2 | |
| SCHEMBL3277957 | 0.77 | CA2 (0.35) | CA2MAPK1CA1TSHRCYP3A4 | |
| SCHEMBL7781244 | 0.77 | TSHR (0.40) | CA2MAPK1CA1TSHRCYP3A4 | |
| SCHEMBL14690765 | 0.76 | CA2 (0.39) | CA2MAPK1CA1SLC1A3SLC1A2 | |
| SCHEMBL7781250 | 0.75 | HCAR2 (0.44) | CA2MAPK1CA1TSHRATM | |
| SCHEMBL7781247 | 0.75 | HCAR2 (0.44) | CA2MAPK1CA1TSHRATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2742091-B1 | THE USE OF ALUMINIUM DIBROMOSALICYLATE, A PROCESS FOR PREPARING NON-FLAMMABLE ORGANIC PLASTICS, AND A FLAME RETARDANT COMPOSITION FOR ITS PREPARATION | Synthos Sa (PL) | 2015-11-04 | — | — | EP | disclosed |
| EP-2742091-A1 | THE USE OF ALUMINIUM DIBROMOSALICYLATE, A PROCESS FOR PREPARING NON-FLAMMABLE ORGANIC PLASTICS, AND A FLAME RETARDANT COMPOSITION FOR ITS PREPARATION | Synthos S.A. (PL) | 2014-06-18 | — | — | EP | disclosed |
| WO-2013022361-A1 | THE USE OF ALUMINIUM DIBROMOSALICYLATE, A PROCESS FOR PREPARING NON-FLAMMABLE ORGANIC PLASTICS, AND A FLAME RETARDANT COMPOSITION FOR ITS PREPARATION | SYNTHOS S.A. (PL) | 2013-02-14 | — | — | WO | disclosed |
| EP-0439079-B1 | Method of producing olefin polymer graft copolymers | MONTELL NORTH AMERICA INC (US) | 1996-04-03 | — | — | EP | disclosed |
| US-5140074-A | Grafting unsaturated monomers onto polyolefins using free radical catalysts in an oxygen-free atmosphere | HIMONT INCORPORATED (US) | 1992-08-18 | — | — | US | disclosed |
| EP-0439079-A2 | Method of producing olefin polymer graft copolymers | MONTELL NORTH AMERICA INC. (US) | 1991-07-31 | — | — | EP | disclosed |